Raman Determination of Ligament Tension
韧带张力的拉曼测定
基本信息
- 批准号:7108152
- 负责人:
- 金额:$ 9.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-09-01 至 2008-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): More marginal results and complications occur as a result of knee ligament surgery than of other common surgical procedure. Long-term success rates of anterior cruciate ligament reconstruction range between 75 and 90%. The goal of knee surgery is to restore the normal kinematics of the knee. If the tension is too high, the range of motion of the joint is restricted, resulting in abnormal stresses on the articular cartilage and the menisci, and interfering with the revascularization of the graft. The National Institute of Arthritis and Musculoskeletal and Skin Diseases Strategic plan for FY 2000-2004 lists recommended areas of research which include "research to better understand the environmental variables and patient variables affecting implant performance" and "determination of the optimal treatments and rehabilitation strategies for common sports injuries." The hypothesis of this Phase I application is that Raman spectroscopy can be used to measure the tension jn a ligament graft. This hypothesis is based on the measurements of Wang et al. (2000) who have observed shifts of Raman lines with tension in single rat-tail tendon fibers and our preliminary measurements. An instrument for measuring the Raman spectrum of ligaments and tendons will be constructed and used to collect in vitro data. Measurements of MCL and ACL ligaments as functions of applied stress will be used to demonstrate the feasibility of the proposed technique.
描述(由申请人提供):与其他常见外科手术相比,膝关节韧带手术的边际结果和并发症更多。前交叉韧带重建的长期成功率在75%到90%之间。膝关节手术的目标是恢复膝关节的正常运动学。如果张力太高,关节的活动范围受到限制,导致关节软骨和关节突上的异常应力,并干扰移植物的血管再生。国家关节炎、肌肉骨骼和皮肤病研究所2000-2004财政年度战略计划列出了建议的研究领域,其中包括“更好地了解影响植入物性能的环境变量和患者变量的研究”和“确定常见运动损伤的最佳治疗和康复策略”。“第一阶段应用的假设是,拉曼光谱可用于测量韧带移植物中的张力。这一假设是基于Wang等人(2000)的测量结果和我们的初步测量结果,Wang等人观察到单个鼠尾肌腱纤维中拉曼谱线随张力的变化。将构建用于测量韧带和肌腱的拉曼光谱的仪器并用于收集体外数据。将使用MCL和ACL韧带的测量值作为施加应力的函数来证明所提出的技术的可行性。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Application of Raman scattering to the measurement of ligament tension.
拉曼散射在韧带张力测量中的应用。
- DOI:10.1109/iembs.2008.4649944
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:Winchester,MW;Winchester,LW;Chou,NY
- 通讯作者:Chou,NY
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Leonard William WINCHESTER其他文献
Leonard William WINCHESTER的其他文献
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{{ truncateString('Leonard William WINCHESTER', 18)}}的其他基金
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Knee能区宇宙线原初成份的研究
- 批准号:19665001
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