Optical Imaging of Retinal Blood Circulation

视网膜血液循环的光学成像

• 批准号: 6403088
• 负责人: Leonard William WINCHESTER
• 金额: $ 13.56万
• 依托单位: CW OPTICS, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6403088
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; diagnosis design /evaluation; hemodynamics; histology; image processing; imaging /visualization /scanning; laboratory rabbit; noninvasive diagnosis; ophthalmoscopy; optics; retina circulation; retina circulation disorder

DESCRIPTION (From the Applicant's Abstract): Evaluation of retinal blood flow is an important diagnostic parameter. Standard techniques to clinically evaluate retinal vasculature in humans-direct and indirect ophthalmoscopy, as well as slit lamp examination-do not directly measure retinal blood flow, an assessment that may be pertinent in detecting preclinical alterations of retinal blood flow that may be predictive of significant clinical morbidity. The current application proposes to investigate the feasibility of a new optical imaging technique for realtime, non-invasive, quantitative measurement of retinal blood flow in animals. Phase I will be devoted to the development and evaluation of a prototype and investigating critical engineering milestones for Phase II. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述(摘自申请人的摘要)： 评价视网膜血流量是一项重要的诊断参数。标准 临床评估人类视网膜血管系统的技术-直接和 间接检眼镜检查，以及裂隙灯检查-不要直接 测量视网膜血流量，这项评估可能与检测 临床前视网膜血流的改变可能预示 显著的临床发病率。当前的应用程序建议调查 一种新的光学成像技术的可行性，实时，非侵入性， 动物视网膜血流量的定量测量。第一阶段将是 致力于原型的开发和评估以及调查 第二阶段的关键工程里程碑。 建议的商业应用：不可用