IMAGING SPECTROFLUORIMETER FOR COLONIC DYSPLASIA

用于结肠发育不良的成像分光荧光计

• 批准号: 2643391
• 负责人: STEPHEN FREDERICK FULGHUM
• 金额: $ 42.77万
• 依托单位: NEWTON LABORATORIES
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-07 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2643391
• 关键词: biomedical equipment development; clinical biomedical equipment; clinical research; clinical trials; colon disorder; colon neoplasms; diagnosis design /evaluation; diagnostic tests; endoscopy; fluorescence spectrometry; gastrointestinal imaging /visualization; human subject; image enhancement; neoplasm /cancer diagnosis

The objective of this research is the design, fabrication and test of a commercial prototype of an Imaging Spectrofluorimeter (ISF) for the real-time detection of dysplasia and carcinoma during video endoscopic examinations of the colon. The ISF employs fluorescence spectroscopy to create an enhanced image for the gastroenterologist. Regions of dysplasia are highlighted with false color in the normal video image of the colon. Dysplastic regions of tissue are identified by their reduced fluorescence compared to that of surrounding tissue. The ISF can also detect flat dysplasia, a precancerous condition which is not detectable by visual inspection alone. Flat dysplasia is currently sought through random biopsy and subsequent histological examination by a pathologist. This method has a very low probability of detection. The ISF will significantly increase the probability of detecting such conditions at an early stage by providing a wide area, rapid surveillance capability during endoscopic examinations. PROPOSED COMMERCIAL APPLICATION The proposed ISF system will provide a significant means of reducing cancer morbidity, mortality and costs, and will therefore be of enormous clinical value.

本研究的目的是设计、制造和测试 成像荧光光谱仪（ISF）的商业原型， 视频内窥镜实时检测异型增生和癌 结肠检查。 ISF采用荧光光谱法 为胃肠病学家创建一个增强图像。 地区 在正常的视频图像中， 结肠组织的发育不良区域通过其减少的 与周围组织的荧光相比。 ISF还可以 检测扁平异型增生，这是一种无法检测到的癌前状态 仅通过目视检查。 扁平发育不良目前寻求通过 随机活检和随后由病理学家进行的组织学检查。 这种方法的检测概率非常低。 ISF将 显著增加检测到这些条件的概率， 通过提供大范围的快速监视能力， 在内窥镜检查中。 建议的商业应用 拟议的ISF系统将提供一种重要的手段， 癌症发病率，死亡率和成本，因此将是巨大的 临床价值