IMAGING SPECTROFLUORIMETER FOR COLONIC DYSPLASIA

这项研究的目的是设计、制造和测试 成像荧光光谱仪(ISF)的商业原型 视频内窥镜下异型增生和癌的实时检测 对结肠的检查。ISF使用荧光光谱技术 为胃肠病专家创建增强的图像。地区 异常增生症在正常的视频图像中以假彩色突出显示 冒号。组织的发育不良区域是通过它们的减少来识别的 与周围组织的荧光进行比较。ISF还可以 检测扁平不典型增生，这是一种无法检测到的癌前状态 仅凭肉眼检查。扁平型发育不良目前通过 由病理学家进行随机活检和随后的组织学检查。 这种方法的检测概率非常低。ISF将 显著增加在以下位置检测到此类情况的概率 通过提供大范围、快速的监视能力进行早期阶段 在内窥镜检查期间。 建议的商业应用 拟议的ISF系统将提供一个重要的手段，以减少 癌症发病率、死亡率和成本，因此将是巨大的 临床价值。

The objective of this research is the design, fabrication and test of a commercial prototype of an Imaging Spectrofluorimeter (ISF) for the real-time detection of dysplasia and carcinoma during video endoscopic examinations of the colon. The ISF employs fluorescence spectroscopy to create an enhanced image for the gastroenterologist. Regions of dysplasia are highlighted with false color in the normal video image of the colon. Dysplastic regions of tissue are identified by their reduced fluorescence compared to that of surrounding tissue. The ISF can also detect flat dysplasia, a precancerous condition which is not detectable by visual inspection alone. Flat dysplasia is currently sought through random biopsy and subsequent histological examination by a pathologist. This method has a very low probability of detection. The ISF will significantly increase the probability of detecting such conditions at an early stage by providing a wide area, rapid surveillance capability during endoscopic examinations. PROPOSED COMMERCIAL APPLICATION The proposed ISF system will provide a significant means of reducing cancer morbidity, mortality and costs, and will therefore be of enormous clinical value.