Regulation of histone methylation by polycomb-like proteins

多梳样蛋白对组蛋白甲基化的调节

• 批准号: DP190103407
• 负责人: A/Prof Chen Davidovich
• 金额: $ 31.36万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103407
• 关键词: Regulation; histone; methylation; polycomb; like

This project aims to investigate how polycomb-like proteins regulate polycomb group (PcG) proteins and recruit them to their target genes. During the development of all multicellular organisms, PcG proteins are essential for keeping thousands of genes in a repressed state. PcG proteins are recruited to their target genes with the aid of their Polycomb-like protein cofactors, in a process that is poorly understood mechanistically. This project will determine the mechanism that underpins the recruitment and regulation of PcG proteins by polycomb-like proteins. Outcomes will have relevance for most development processes of multicellular organisms.

该项目旨在研究polycomb like蛋白如何调节polycomb group（PcG）蛋白并将其招募到其靶基因。在所有多细胞生物的发育过程中，PcG蛋白对于保持数千个基因处于抑制状态至关重要。PcG蛋白在其Polycomb样蛋白辅因子的帮助下被募集到其靶基因，这一过程在机制上知之甚少。该项目将确定多梳样蛋白募集和调节PcG蛋白的机制。结果将与多细胞生物的大多数发育过程相关。