课题基金 / 基金详情

TAXOL/TAXOTERE RADIATION STUDIES IN BRAIN TUMOR CELLS

TAXOL/TAXOTERE RADIATION STUDIES IN BRAIN TUMOR CELLS
脑肿瘤细胞中的紫杉醇/紫杉醇辐射研究
批准号：
2700538
负责人：
DENNIS F. DEEN
金额：
$26.16万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
项目状态：
已结题
起止时间：
1996-05-01 至 2000-04-30
来源：
https://reporter.nih.gov/project-details/2700538
关键词：
acid base balance analog brain neoplasms cell cycle cell death combination cancer therapy cytotoxicity drug screening /evaluation glioma ionizing radiation neoplasm /cancer pharmacology neoplasm /cancer radiation therapy neoplastic cell paclitaxel tissue /cell culture

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中文摘要
翻译
描述：这个项目的具体目的是：定义细胞
英文摘要
DESCRIPTION: The specific aims of this project are: to define cell survival and cellular perturbations as a function of drug concentration and duration of exposure, and to determine how the toxicity of these compounds is affected by the pH or cycling status of cells; to test the hypothesis that drug-induced perturbations produce radiopotentiation, and that irradiation of cells alters their drug response by delaying the cell cycle; to determine whether paclitaxel and docetaxel alter recovery from radiation-induced damage, and, to investigate the efficacy of combined treatment with paclitaxel or docetaxel and radiation in vivo.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
Characterization of human glioblastoma xenograft growth in athymic mice.
无胸腺小鼠中人胶质母细胞瘤异种移植物生长的特征。
DOI： --
发表时间： 1998
期刊： In vivo (Athens, Greece)
影响因子： --
作者： [Ozawa,T, Wang,J, Hu,LJ, Lamborn,KR, Bollen,AW, Deen,DF]
通讯作者： Deen,DF
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海外基金