TAXOL/TAXOTERE RADIATION STUDIES IN BRAIN TUMOR CELLS

脑肿瘤细胞中的紫杉醇/紫杉醇辐射研究

• 批准号: 2700538
• 负责人: DENNIS F. DEEN
• 金额: $ 26.16万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2700538
• 关键词: acid base balance; analog; brain neoplasms; cell cycle; cell death; combination cancer therapy; cytotoxicity; drug screening /evaluation; glioma; ionizing radiation; neoplasm /cancer pharmacology; neoplasm /cancer radiation therapy; neoplastic cell; paclitaxel; tissue /cell culture

DESCRIPTION: The specific aims of this project are: to define cell survival and cellular perturbations as a function of drug concentration and duration of exposure, and to determine how the toxicity of these compounds is affected by the pH or cycling status of cells; to test the hypothesis that drug-induced perturbations produce radiopotentiation, and that irradiation of cells alters their drug response by delaying the cell cycle; to determine whether paclitaxel and docetaxel alter recovery from radiation-induced damage, and, to investigate the efficacy of combined treatment with paclitaxel or docetaxel and radiation in vivo.

描述：该项目的具体目标是：定义细胞 存活率和细胞扰动作为药物浓度的函数 以及暴露的持续时间，并确定这些物质的毒性 化合物受pH值或细胞循环状态的影响;测试 药物引起的扰动产生的假设 辐射增强，并且细胞的辐射改变了它们的药物 通过延迟细胞周期来响应;以确定是否 紫杉醇和多西他赛改变从辐射诱导的损伤中的恢复， 并观察紫杉醇联合治疗的疗效 或多西他赛和放射。

项目成果

Characterization of human glioblastoma xenograft growth in athymic mice.

无胸腺小鼠中人胶质母细胞瘤异种移植物生长的特征。

• 发表时间: 1998
• 期刊: In vivo (Athens, Greece)
• 作者: Ozawa,T;Wang,J;Hu,LJ;Lamborn,KR;Bollen,AW;Deen,DF
• 通讯作者: Deen,DF