TAXOL/TAXOTERE RADIATION STUDIES IN BRAIN TUMOR CELLS

脑肿瘤细胞中的紫杉醇/紫杉醇辐射研究

• 批准号: 2414304
• 负责人: DENNIS F. DEEN
• 金额: $ 26.12万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2414304
• 关键词: acid base balance; analog; brain neoplasms; cell cycle; cell death; combination cancer therapy; cytotoxicity; drug screening /evaluation; glioma; ionizing radiation; neoplasm /cancer pharmacology; neoplasm /cancer radiation therapy; neoplastic cell; paclitaxel; tissue /cell culture

DESCRIPTION: The specific aims of this project are: to define cell survival and cellular perturbations as a function of drug concentration and duration of exposure, and to determine how the toxicity of these compounds is affected by the pH or cycling status of cells; to test the hypothesis that drug-induced perturbations produce radiopotentiation, and that irradiation of cells alters their drug response by delaying the cell cycle; to determine whether paclitaxel and docetaxel alter recovery from radiation-induced damage, and, to investigate the efficacy of combined treatment with paclitaxel or docetaxel and radiation in vivo.

描述：该项目的具体目标是：定义细胞 生存和细胞扰动作为药物浓度的函数 和暴露时间，并确定这些物质的毒性如何 化合物受 pH 值或细胞循环状态的影响；测试 药物引起的扰动产生的假设 放射增强，并且细胞的照射改变了它们的药物 通过延迟细胞周期做出反应；以确定是否 紫杉醇和多西紫杉醇改变辐射引起的损伤的恢复， 并研究紫杉醇联合治疗的疗效 或多西紫杉醇和体内辐射。