TAXOL/TAXOTERE RADIATION STUDIES IN BRAIN TUMOR CELLS

描述：该项目的具体目标是：定义细胞 生存和细胞扰动作为药物浓度的函数 和暴露时间，并确定这些物质的毒性如何 化合物受 pH 值或细胞循环状态的影响；测试 药物引起的扰动产生的假设 放射增强，并且细胞的照射改变了它们的药物 通过延迟细胞周期做出反应；以确定是否 紫杉醇和多西紫杉醇改变辐射引起的损伤的恢复， 并研究紫杉醇联合治疗的疗效 或多西紫杉醇和体内辐射。

DESCRIPTION: The specific aims of this project are: to define cell survival and cellular perturbations as a function of drug concentration and duration of exposure, and to determine how the toxicity of these compounds is affected by the pH or cycling status of cells; to test the hypothesis that drug-induced perturbations produce radiopotentiation, and that irradiation of cells alters their drug response by delaying the cell cycle; to determine whether paclitaxel and docetaxel alter recovery from radiation-induced damage, and, to investigate the efficacy of combined treatment with paclitaxel or docetaxel and radiation in vivo.