Machineries that maintain mitochondrial architecture

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This project aims to define and characterise the protein machines that give mitochondria their characteristic shape in different cellular tissues. Innovative approaches involving gene editing and quantitative proteomics with molecular cell biology will be employed. This project expects to generate new knowledge in protein-mediated membrane shaping and mechanisms by which signaling occurs across multiple membranes. The project outcomes should include enhanced capacity for fundamental cell biology research in Australia. The project anticipates the contribution of new tools for structural biology, benefiting therapeutic and biotechnology applications and the training of young researchers in frontier technologies.