Machineries that maintain mitochondrial architecture

这个项目的目的是定义和识别蛋白质机器，使线粒体在不同的细胞组织中具有特征性的形状。将采用涉及基因编辑和定量蛋白质组学与分子细胞生物学的创新方法。该项目预计将产生新的知识，蛋白质介导的膜成形和机制，信号发生在多个膜。该项目的成果应包括提高澳大利亚基础细胞生物学研究的能力。该项目预期结构生物学新工具的贡献，有益于治疗和生物技术应用，并培训年轻研究人员掌握前沿技术。

This project aims to define and characterise the protein machines that give mitochondria their characteristic shape in different cellular tissues. Innovative approaches involving gene editing and quantitative proteomics with molecular cell biology will be employed. This project expects to generate new knowledge in protein-mediated membrane shaping and mechanisms by which signaling occurs across multiple membranes. The project outcomes should include enhanced capacity for fundamental cell biology research in Australia. The project anticipates the contribution of new tools for structural biology, benefiting therapeutic and biotechnology applications and the training of young researchers in frontier technologies.