Dynamics of mitochondrial cristae in life and death

这项申请寻求使用创新的方法来解决线粒体中大量的结构安排在正常细胞功能期间是如何处理的，以及在细胞死亡期间是如何调节的。这项研究建立在一个在线粒体生物学和细胞死亡方面拥有世界领先专业知识的团队的发现基础上，并带来了细胞生物学、蛋白质组学和成像领域的创新和尖端技术。这些发现将为蜂窝组织提供新的基本见解，并揭示新的通信原则。受训者将获得高度可翻译和其他科学努力领域所需的技术方面的技能。因此，所获得的专门知识将扩大澳大利亚的研究能力。

This application seeks to use innovative approaches to address how massive structural arrangements in mitochondria are dealt with during normal cell function, and modulated during cell death. The study builds on discoveries made by a team with world-leading expertise in mitochondrial biology and cell death – and brings innovative, cutting-edge techniques in cell biology, proteomics and imaging. The findings will provide new fundamental insights into cellular organisation and uncover new principles of communication. Trainees will gain skills in technologies that are highly translatable and in demand in other areas of scientific endeavours. As such the expertise obtained will expand Australian research capabilities.