A unified approach to studies on mitochondrial biogenesis

线粒体生物发生研究的统一方法

• 批准号: LX0454399
• 负责人: Prof Michael Ryan
• 金额: $ 2.82万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage - International
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-02-29 至 2008-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LX0454399
• 关键词: unified; approach; studies; mitochondrial; biogenesis

Mitochondria supply the cell with the majority of its energy as well as performing other key functions. How mitochondrial processes are regulated within the cell is an important area of biology. The broad aims of this collaboration are to analyse processes involved in mitochondrial biogenesis using yeast and mammalian cells as model systems. In particular the protein import processes and mitochondrial stress responses will be studied. The outcomes of this work will enable us to gain an appreciation of the similarities and differences in processes that exist between organisms so that general, unifying models can be made.

线粒体为细胞提供大部分能量，并执行其他关键功能。线粒体过程如何在细胞内调节是生物学的一个重要领域。这项合作的广泛目标是使用酵母和哺乳动物细胞作为模型系统来分析线粒体生物发生所涉及的过程。特别是蛋白质输入过程和线粒体应激反应将进行研究。这项工作的结果将使我们能够了解生物体之间存在的过程的相似性和差异，以便能够建立通用的统一模型。