Defining the machinery for mitochondrial turnover governed by the Parkinson’s Disease proteins PINK1 and Parkin

定义由帕金森病蛋白 PINK1 和 Parkin 控制的线粒体周转机制

• 批准号: nhmrc : 1106471
• 负责人: Prof Michael Ryan
• 金额: $ 29.77万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-machinery-mitochondrial-pink1-parkin/662913
• 关键词: Defining; machinery; mitochondrial; turnover; governed

Parkinson’s disease is a degenerative disorder of the central nervous system in which the underlying cause is mostly unknown. To pave the way to a better understanding of what goes wrong, this study will investigate the function of PINK1 and Parkin, two proteins that are mutated in inherited forms of the disease that play important roles in maintaining cellular health. The results of this study will be used in exploring new therapeutic targets for the treatment of Parkinson’s disease symptoms.

帕金森病是一种中枢神经系统退行性疾病，其根本原因大多未知。为了更好地了解问题所在，这项研究将研究 PINK1 和 Parkin 的功能，这两种蛋白质在遗传性疾病中发生突变，在维持细胞健康方面发挥着重要作用。这项研究的结果将用于探索治疗帕金森病症状的新治疗靶点。