PHYSIOLOGY OF CIRCANNUAL RHYTHMS

这项拟议的研究评估了几种生理因素的影响 对金毛地松鼠昼夜节律的刺激， 包括体内内源性周期性波动的作用 温度对昼夜节律组织和昼夜节律的影响 代谢率。通常与体温下降相关的 随着冬眠季节的到来，将会被封锁 昼夜夹带和代谢率的昼夜变化 下定决心。产前光周期在时序/发生中的作用 幼年松鼠的周年节律也将在 松鼠要么保持在恒定的光线下，以消除光周期信号， 或者是怀孕期间的模拟自然光周期。时间和/或 在这些雌性后代中出现每年一次的节律将是 检查过了。睾酮(T)抑制冬眠的神经部位 将在植入含有T的管子的雄性松鼠身上进行检查 进入含有T受体的神经部位，并牵涉到 温度调节。视交叉上核的抑制作用 (SCN)在男性冬眠和生殖的一年一次的时间 将对松鼠进行检查，以确定该核是否起作用 同样，在男性和女性身上也是如此，以限制冬眠和生殖 一年中特定的时间。这项研究可能会对该领域的发展有所帮助。 用于治疗每年一次的人类疾病的干预措施 基础。

The proposed research evaluates the impact of several physiological stimuli on circannual rhythms of golden-mantled ground squirrels, including the role of endogenous circannual fluctuations in body temperature on circannual variations in circadian organization and metabolic rate. The decrease in body temperature normally associated with the hibernation season will be blocked and the presence of circannual variations in circadian entrainment and metabolic rate determined. The role of prenatal photoperiod in the timing/generation of circannual rhythms of young squirrels will also be examined in squirrels kept either in constant light, to eliminate photoperiod cues, or a simulated natural photoperiod during gestation. The timing and/or presence of circannual rhythms in the offspring of these females will be examined. Neural sites at which testosterone (T) suppresses hibernation will be examined in male squirrels implanted with cannulae containing T into neural sites that contain T receptors and implicated in thermoregulation. The inhibitory role of the suprachiasmatic nucleus (SCN) in circannual timing of hibernation and reproduction in male squirrels will be examined to determine if this nucleus functions similarly in males as in females to limit hibernation and reproduction to particular times of year. This research may help in the development of interventions for treating human disorders that have a circannual basis.