PHYSIOLOGY OF CIRCANNUAL RHYTHMS

昼夜节律的生理学

• 批准号: 6078151
• 负责人: DAVID A FREEMAN
• 金额: $ 3.84万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6078151
• 关键词: bioperiodicity; body temperature regulation; early experience; hibernation; hormone receptor; hormone regulation /control mechanism; implant; neural information processing; neuroendocrine system; photostimulus; reproduction; squirrel; suprachiasmatic nucleus; testosterone

The proposed research evaluates the impact of several physiological stimuli on circannual rhythms of golden-mantled ground squirrels, including the role of endogenous circannual fluctuations in body temperature on circannual variations in circadian organization and metabolic rate. The decrease in body temperature normally associated with the hibernation season will be blocked and the presence of circannual variations in circadian entrainment and metabolic rate determined. The role of prenatal photoperiod in the timing/generation of circannual rhythms of young squirrels will also be examined in squirrels kept either in constant light, to eliminate photoperiod cues, or a simulated natural photoperiod during gestation. The timing and/or presence of circannual rhythms in the offspring of these females will be examined. Neural sites at which testosterone (T) suppresses hibernation will be examined in male squirrels implanted with cannulae containing T into neural sites that contain T receptors and implicated in thermoregulation. The inhibitory role of the suprachiasmatic nucleus (SCN) in circannual timing of hibernation and reproduction in male squirrels will be examined to determine if this nucleus functions similarly in males as in females to limit hibernation and reproduction to particular times of year. This research may help in the development of interventions for treating human disorders that have a circannual basis.

提出的研究评估了几种生理因素的影响

项目成果

Temperature-independence of circannual variations in circadian rhythms of golden-mantled ground squirrels.

金披地松鼠昼夜节律的昼夜节律变化与温度无关。

• DOI: 10.1177/074873000129001341
• 发表时间: 2000
• 期刊: Journal of biological rhythms
• 影响因子: 3.5
• 作者: Freeman,DA;Zucker,I
• 通讯作者: Zucker,I