DENTAL AMALGAMS AND NEUROPSYCHOLOGICAL FUNCTION

牙科汞合金和神经心理功能

• 批准号: 2654454
• 负责人: Pam R Factor-Litvak
• 金额: $ 66.81万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2000-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2654454
• 关键词: attention; clinical research; dental amalgam; emotions; human middle age (35-64); human subject; memory; mercury; mercury poisoning; neuropsychological tests; neuropsychology; questionnaires; space perception; urinalysis; visual perception; vocabulary

DESCRIPTION: There is considerable evidence that some mercury from "silver fillings" distributes to body tissues, particularly the brain. Occupational exposure to mercury vapor is associated with increases in the prevalence of tremor, peripheral neuropathy, cerebellar dysfunction, and abnormal measures of balance. Occupational exposure also is associated with deficits in neuropsychological tests of memory and visuospatial ability and increased reports of subjective symptoms and disturbed mood. The investigators propose to address the hypothesis that low dose mercury exposure, derived from amalgams in the mouth, may be associated with evidence of neurological dysfunction and neuropsychological deficits. By conducting a cross-sectional study, the investigators will test whether amalgam-derived mercury is adversely associated with tests of neurological function, visuospatial ability, memory and attention/executive function. The study sample will comprise approximately 750-840 Columbia University personnel, ages 30-49 years. Based on preliminary work, it is known that the cohort will have a wide range of visible amalgam surfaces. Measures of exposure will be urinary mercury concentration and the numbers of amalgam surfaces, total and occlusal. The proposed outcome measures tap a wide range of neurological and neuropsychological functions. A variety of tests will assess four domains of neuropsychological function: visuomotor/visuospatial function, memory, attention and executive function, and vocabulary. A self-reported questionnaire of mood and a symptom checklist will also be administered. In addition, the investigators will collect quantitative measures of postural sway. After control for confounding variables, including measures of social desirability and hypochondriasis, the dose-response relationships between exposure and each functional domain will be described. Results from this study will have potential public health applications. Adverse associations, if found, might lead to less use of mercury amalgams. Alternatively, evidence favoring the null hypothesis would allay widespread fears that a variety of health problems may be associated with amalgam exposure.

描述：有相当多的证据表明，一些汞从“银 “填充物”分布到身体组织，特别是大脑。 职业 接触汞蒸气与以下疾病的患病率增加有关： 震颤、周围神经病变、小脑功能障碍和异常测量 平衡。 职业暴露也与以下缺陷有关： 记忆力和视觉空间能力的神经心理学测试， 报告主观症状和不安情绪。 调查人员 建议解决这一假设，即低剂量汞接触， 从汞合金在嘴里，可能与证据的神经 功能障碍和神经心理缺陷。 通过进行横断面研究，研究人员将测试是否 汞齐衍生的汞与神经系统检查有不利关系， 功能、视觉空间能力、记忆力和注意力/执行功能。 研究样本将包括大约750-840名哥伦比亚大学 年龄30-49岁。 根据初步工作，已知， 该群组将具有大范围的可见汞合金表面。 措施 暴露将是尿汞浓度和汞合金的数量 表面，总的和咬合的。 拟议的成果衡量标准利用了广泛的 一系列神经和神经心理功能。 各种测试 将评估神经心理功能的四个领域： 视觉/视觉空间功能，记忆，注意力和执行功能， 和词汇。 一份关于情绪和症状的自我报告问卷 还将管理检查表。 此外，调查人员将 收集姿势摇摆的定量测量。 控制后， 混杂变量，包括社会期望的测量， 剂量反应关系，暴露和每一个 将描述功能域。 这项研究的结果将具有潜在的公共卫生应用。 如果发现不利的关联，可能会导致汞合金的使用减少。 或者，支持零假设的证据将减轻广泛的 人们担心汞合金可能会引发各种健康问题 exposure.