ERP CORRELATES OF NORMAL AND ABNORMAL MEMORY

描述(改编自申请人的摘要)： 拟议的研究是记录大脑的ERPs，以便提供 与外显和外显相关的认知活动的时空映射 完整人脑的内隐记忆功能。的基本前提是 这一建议是关于潜在认知的推论 结构与认知相关事件相关电位的脑生成器 组件可以通过汇聚多个源获得 信息包括：1)使用临床人群，如患者 患有阿尔茨海默病和精神分裂症，有良好的记忆力和其他认知能力 2)正常认知发育和衰老的研究 提供了研究已知不同的个体群体的机会，例如 衰老过程在外显和内隐记忆任务中展开；以及3) 脑损伤所致遗忘症患者的使用情况。这个 应用还包括外显记忆的两个方面的研究， 来源记忆和再认记忆，分别依赖于额叶 和内侧颞叶，从而提供：a)测试的机会 关于精神分裂症脑功能障碍可能部位的相互竞争的假说 和相关的症状学；b)有机会更好地确定 老年人的年龄相关性记忆缺陷及其可能的神经部位 以及c)评估不同发展水平的机会 这两个外显记忆功能(及其基础功能)的变化率 神经回路)。所有这些都允许不同年龄或不同年龄的人之间存在ERP差异 临床群体应立足于认知过程的差异。 最后，使用电流源密度(CSD)分析和脑电 用于估计大脑空间构型的源分析(BESA) 地表记录的事件相关电位背后的发电机是值得注意的。 候选人的职业提升和持续发展将是 通过以下方式得到支持和培养：1)在 开展拟议的研究；2)广泛合作和 咨询该领域的其他专家；3)学习会议和 关于地形技术和震源定位的讲习班；4)新的 研究，包括对ERP记忆相关现象的研究 精神分裂症，以及脑损伤伴遗忘症患者；以及5) 使用独特的部门资源和环境，致力于 了解精神障碍，如精神分裂症和阿尔茨海默病。

DESCRIPTION (Adapted from applicant's abstract): The broad objective of the proposed research is to record brain ERPs in order to provide a spatio-temporal mapping of cognitive activity related to explicit and implicit memory function in the intact human brain. The basic premise of this proposal is that inferences about both the underlying cognitive architecture and the brain generators of the cognition-related ERP components can be obtained through the convergence of several sources of information including: 1) the use of clinical populations, such as patients with AD and schizophrenia, with well-documented memory and other cognitive deficits; 2) the study of normal cognitive development and aging which provides the opportunity to study groups of individuals known to differ, as the aging process unfolds, on explicit and implicit memory tasks; and 3) the use of patients with amnestic disorders due to brain injuries. The application also includes the study of two aspects of explicit memory, source and recognition memory, that depend, respectively, upon the frontal and medial temporal lobes, thus providing: a) the opportunity to test competing hypotheses as to putative sites of schizophrenic brain dysfunction and associated symptomatology; b) the opportunity to better characterize age-related memory deficits and their putative neural sites in the older population; and c) the opportunity to assess the differential developmental rates of change in these two explicit memory functions (and their underlying neural circuits). All of the above allow ERP differences between age or clinical groups to be anchored in differences in cognitive processes. Finally, the use of current source density (CSD) analysis and brain electric source analysis (BESA) for estimating the spatial configuration of brain generators underlying the surface-recorded ERPs is notable. The candidate's career enhancement and continuing development will be sustained and fostered by: 1) the experience to be gained during the conduct of the proposed research; 2) extensive collaborations and consultation with other experts in the field; 3) study sessions and workshops in topographic techniques and source localization; 4) new areas of research, including studies of ERP memory-related phenomena in schizophrenia, and in brain injured patients with amnestic disorders; and 5) use of unique departmental resources and environment dedicated to better understanding of mental disorders such as schizophrenia and AD.