AGE-RELATED ERP MEASURES IN ALZHEIMER'S DISEASE

阿尔茨海默病中与年龄相关的 ERP 测量

• 批准号: 3121934
• 负责人: DAVID FRIEDMAN
• 金额: $ 16.19万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-15 至 1994-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3121934
• 关键词: Alzheimer's disease; auditory stimulus; bias; brain electrical activity; cognition; concept; conditioning; electrical potential; electroencephalography; evoked potentials; human age group; human old age (65+); human subject; memory; neural information processing; neuropsychological tests; performance; semantics; stimulus /response; stimulus interval; tomography; visual perception; visual stimulus

Event-related brain potentials (ERPs) and performance measures will be recorded from patients with probable Alzheimer's disease (PAD), and age- matched normal controls. The main thrust of the proposal is to assess performance on explicit and implicit tests of memory in carefully controlled designs, in an attempt to uncover the physiological underpinnings of memory deficiencies in PAD reported in the behavioral literature. Three experiments are proposed: 1) the first asks the question how do PAD subjects differ from age-matched controls (behaviorally and with respect to ERPs) in the ways in which they process pictorial and lexical input on-line, and the ways in which they remember and retrieve such input during implicit (fragment completion) and explicit (recognition) testing; 2) the second is aimed at assessing the adequacy of encoding operations at study. Orienting task will be used to manipulate encoding activity. ERP activity at study will be computed, separately by orienting task, as a function of subsequent stem completion (implicit) and cued recall (explicit) performance. This activity (i.e., the ERP "memory effect") is expected to differ between the groups as a function of differences in encoding operations; 3) the third seeks to determine if the ERP and behavioral repetition effect will be modulated by the number of repetitions of an item (i.e., its "memory strength") similarly in PAD and age-matched control subjects. In constrast to the previous experiment, memory will only be tested implicitly, and the focus is on retention. In general, it is also expected that the amplitude of the ERP old/new repetition effect will reflect the magnitude of priming during on-line and delayed memory tasks. ERPs will be recorded from several scalp placements in order to determine whether scalp distributions and, by implication, their intracranial generators, differ systematically between the groups. The data will be relevant to age-related pathological changes in memory function, and their physiological underpinnings.

事件相关脑电位(ERPs)和绩效指标将 从可能患有阿尔茨海默病(PAD)的患者那里记录下来，以及年龄- 与正常对照组相匹配。该提案的主旨是评估 学习记忆的外显和内隐测验成绩 受控设计，试图揭示生理上的 在行为学中报道的PAD记忆缺陷的基础 文学。提出了三个实验：1)第一个实验要求 问PAD受试者与年龄匹配的对照组(行为)有何不同 以及关于事件相关事件)以它们处理图像和 在线词汇输入，以及他们记忆和检索的方式 在隐式(片段补全)和显式(识别)期间的这种输入 测试；2)第二个目的是评估编码的充分性 正在研究中的手术。定向任务将用于操作编码 活动。研究中的ERP活动将通过定向单独计算 任务，作为后续词干补全(隐式)和提示的函数 召回(显性)绩效。这一活动(即事件相关电位“记忆” 效果“)预计在不同组之间作为以下函数而不同 编码操作的差异；3)第三个试图确定 事件相关电位和行为重复效应将被调节的数量 物品的重复次数(即其“记忆强度”)在PAD和 年龄匹配的对照组受试者。与前一次实验相比， 记忆只会被隐含地测试，重点是保持。在……里面 一般情况下，也预计新旧ERP的幅度 重复效应将反映在线和在线启动的大小 延迟的记忆任务。将从几个头皮放置位置记录事件相关电位 为了确定头皮的分布，也就是说， 他们的颅内发生器在不同的组之间有系统的不同。 这些数据将与年龄相关的记忆病理变化相关 功能以及它们的生理基础。