ERP CORRELATES OF NORMAL AND ABNORMAL MEMORY

ERP 与正常和异常记忆相关

• 批准号: 2889825
• 负责人: DAVID FRIEDMAN
• 金额: $ 10.81万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2889825
• 关键词: Alzheimer's disease; aging; brain electrical activity; brain injury; clinical research; cognition; evoked potentials; human old age (65+); human subject; memory; performance; psychological tests; schizophrenia; young adult human (21-34)

DESCRIPTION (Adapted from applicant's abstract): The broad objective of the proposed research is to record brain ERPs in order to provide a spatio-temporal mapping of cognitive activity related to explicit and implicit memory function in the intact human brain. The basic premise of this proposal is that inferences about both the underlying cognitive architecture and the brain generators of the cognition-related ERP components can be obtained through the convergence of several sources of information including: 1) the use of clinical populations, such as patients with AD and schizophrenia, with well-documented memory and other cognitive deficits; 2) the study of normal cognitive development and aging which provides the opportunity to study groups of individuals known to differ, as the aging process unfolds, on explicit and implicit memory tasks; and 3) the use of patients with amnestic disorders due to brain injuries. The application also includes the study of two aspects of explicit memory, source and recognition memory, that depend, respectively, upon the frontal and medial temporal lobes, thus providing: a) the opportunity to test competing hypotheses as to putative sites of schizophrenic brain dysfunction and associated symptomatology; b) the opportunity to better characterize age-related memory deficits and their putative neural sites in the older population; and c) the opportunity to assess the differential developmental rates of change in these two explicit memory functions (and their underlying neural circuits). All of the above allow ERP differences between age or clinical groups to be anchored in differences in cognitive processes. Finally, the use of current source density (CSD) analysis and brain electric source analysis (BESA) for estimating the spatial configuration of brain generators underlying the surface-recorded ERPs is notable. The candidate's career enhancement and continuing development will be sustained and fostered by: 1) the experience to be gained during the conduct of the proposed research; 2) extensive collaborations and consultation with other experts in the field; 3) study sessions and workshops in topographic techniques and source localization; 4) new areas of research, including studies of ERP memory-related phenomena in schizophrenia, and in brain injured patients with amnestic disorders; and 5) use of unique departmental resources and environment dedicated to better understanding of mental disorders such as schizophrenia and AD.

描述（改编自申请人的摘要）： 一项被提议的研究是记录大脑的ERPs， 与外显和 内隐记忆功能。 的基本前提 这一提议是， 认知相关事件相关电位的结构和脑发生器 成分可以通过几个来源的收敛， 信息包括：1）使用临床人群，如患者 患有AD和精神分裂症，有记录的记忆和其他认知功能 缺陷; 2）正常认知发展和衰老的研究， 提供了研究已知不同的个体群体的机会， 衰老过程在外显和内隐记忆任务中展开; 3） 用于因脑损伤导致的健忘症患者。 的 应用还包括外显记忆的两个方面的研究， 来源和识别记忆，分别取决于额叶 和内侧颞叶，从而提供：a）测试的机会 关于精神分裂症脑功能障碍的假定部位的相互竞争的假说 和相关的神经病学; B）更好地表征 老年人与年龄相关的记忆缺陷及其假定的神经部位 （c）有机会评估发展差异 这两种外显记忆功能的变化率（及其潜在的 神经回路）。 所有这些都允许年龄或年龄之间的ERP差异， 临床群体以认知过程的差异为基础。 最后利用电流源密度（CSD）分析和脑电 源分析（BESA）用于估计脑的空间构型 发生器的表面记录ERP是值得注意的。 候选人的职业提升和持续发展将 维持和促进的：1）经验，以获得在 （2）广泛的合作， 与该领域的其他专家进行磋商; 3）研究会议， 地形技术和震源定位讲习班; 4） 研究，包括ERP记忆相关现象的研究， 精神分裂症和患有遗忘症的脑损伤患者;以及5） 利用独特的部门资源和环境，致力于更好地 了解精神分裂症和AD等精神疾病。