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ERP CORRELATES OF NORMAL AND ABNORMAL MEMORY

ERP 与正常和异常记忆相关

基本信息

批准号：
6185310
负责人：
DAVID FRIEDMAN
金额：
$ 10.81万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-08-01 至 2001-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6185310
关键词：
Alzheimer's disease aging brain electrical activity brain injury clinical research cognition evoked potentials human old age (65+) human subject memory performance psychological tests schizophrenia young adult human (21-34)

项目摘要

DESCRIPTION (Adapted from applicant's abstract): The broad objective of the proposed research is to record brain ERPs in order to provide a spatio-temporal mapping of cognitive activity related to explicit and implicit memory function in the intact human brain. The basic premise of this proposal is that inferences about both the underlying cognitive architecture and the brain generators of the cognition-related ERP components can be obtained through the convergence of several sources of information including: 1) the use of clinical populations, such as patients with AD and schizophrenia, with well-documented memory and other cognitive deficits; 2) the study of normal cognitive development and aging which provides the opportunity to study groups of individuals known to differ, as the aging process unfolds, on explicit and implicit memory tasks; and 3) the use of patients with amnestic disorders due to brain injuries. The application also includes the study of two aspects of explicit memory, source and recognition memory, that depend, respectively, upon the frontal and medial temporal lobes, thus providing: a) the opportunity to test competing hypotheses as to putative sites of schizophrenic brain dysfunction and associated symptomatology; b) the opportunity to better characterize age-related memory deficits and their putative neural sites in the older population; and c) the opportunity to assess the differential developmental rates of change in these two explicit memory functions (and their underlying neural circuits). All of the above allow ERP differences between age or clinical groups to be anchored in differences in cognitive processes. Finally, the use of current source density (CSD) analysis and brain electric source analysis (BESA) for estimating the spatial configuration of brain generators underlying the surface-recorded ERPs is notable. The candidate's career enhancement and continuing development will be sustained and fostered by: 1) the experience to be gained during the conduct of the proposed research; 2) extensive collaborations and consultation with other experts in the field; 3) study sessions and workshops in topographic techniques and source localization; 4) new areas of research, including studies of ERP memory-related phenomena in schizophrenia, and in brain injured patients with amnestic disorders; and 5) use of unique departmental resources and environment dedicated to better understanding of mental disorders such as schizophrenia and AD.

描述（改编自申请人的摘要）：该项目的总体目标拟议的研究是记录大脑 ERP，以便提供与外显和认知相关的认知活动的时空映射完整的人脑中的内隐记忆功能。基本前提是这个提议是关于潜在认知的推论认知相关 ERP 的架构和大脑生成器组件可以通过多个来源的收敛来获得信息包括：1）临床人群的使用，例如患者患有 AD 和精神分裂症，具有有据可查的记忆力和其他认知能力赤字； 2）正常认知发展和衰老的研究提供了研究已知不同个体的群体的机会，例如衰老过程在显性和隐性记忆任务上展开； 3）使用因脑损伤而患有遗忘症的患者。这应用还包括外显记忆两个方面的研究，源记忆和识别记忆，分别取决于额叶和内侧颞叶，从而提供：a) 测试的机会关于精神分裂症脑功能障碍的假定部位的相互竞争的假设以及相关的症状学； b) 更好地表征的机会与年龄相关的记忆缺陷及其在老年人中的假定神经部位人口; c) 评估差异发展的机会这两个显式记忆功能（及其潜在的变化率）的变化率神经回路）。以上所有因素都允许年龄或年龄之间的 ERP 差异临床分组以认知过程的差异为基础。最后，利用电流源密度（CSD）分析和脑电用于估计大脑空间配置的源分析（BESA）表面记录 ERP 背后的发电机值得注意。候选人的职业提升和持续发展将维持和促进： 1）在过程中获得的经验进行拟议的研究； 2）广泛的合作和与该领域其他专家协商； 3）学习课程和地形技术和源定位讲习班； 4）新领域研究，包括 ERP 记忆相关现象的研究精神分裂症和患有遗忘症的脑损伤患者；和 5) 利用得天独厚的部门资源和环境致力于更好了解精神分裂症和 AD 等精神疾病。