HA AND TI COATINGS ON BONE/IMPLANT INTERACTIONS

HA 和 TI 涂层对骨/种植体相互作用的影响

• 批准号: 2703647
• 负责人: JOO L. ONG
• 金额: $ 5.08万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2703647
• 关键词: X ray crystallography; biomaterial evaluation; biomaterial interface interaction; bone development; dental implants; dogs; histology; hydroxyapatites; infrared spectrometry; interferometry; longitudinal animal study; photoelectron spectrometry; physiologic bone resorption; plasma; surface property; tensile strength; tissue /cell culture; titanium

DESCRIPTION: Biomaterials surfaces play an important role in the overall implant success. The objectives of this study are: to compare the performance of surface treated Ti implants to non-surface treated Ti implants in relation to bone implant interface and bone strength; and to investigate the long-term impact on bone remodeling as a result of loading the plasma sprayed titanium implants, plasma sprayed HA implants and non-surface treated TI implants. Aim will evaluate in vitro properties of plasma sprayed HA surfaces and compare their in vitro properties in cell culture medium containing serum with that of TI coated implants treated similarly. Aim 2 will compare the in vivo performance in dogs of plasma sprayed HA and TI implants with non- treated TI implants in terms of bone implant interface, interfacial strength, and coating resorption. Hypotheses to be tested are: 1) that the surface properties of HA coatings will be altered following in vitro incubation and thus will affect their in vivo stability; 2) prior to loading, the presence of plasma sprayed HA and TI coatings will result in an increase in bone implant bonding strength an greater bone apposition when compared to non-surface treated TI surfaces; and 3) after one year loading, differences in reverse torque and bone apposition will be observed among plasma sprayed HA and TI implants, and untreated TI implants. At present, implants are often placed clinically prior to the conduct of basic experimental studies elucidating the remodeling mechanisms that may enhance clinical serviceability. Data generated by this pilot study could provide needed information on HA surface properties, provide preliminary information on relationships among the different surfaced implants, and provide a basis for future long-term in vivo clinical studies, while suggesting an optimum surface treatment required for maximum implant stability. These result could reduce implant failures which are costly in terms of trauma, time, and money.

描述：生物材料表面在生物医学领域发挥着重要作用。 总体植入成功率。 本研究的目的是：比较 表面处理钛植入物与未表面处理钛植入物的性能 钛植入物与骨植入物界面和骨强度的关系;以及 为了研究长期影响骨重建的结果， 加载等离子喷涂钛植入物、等离子喷涂HA植入物 和未经表面处理的TI植入物。 Aim将在体外进行评价 等离子喷涂HA表面的性能，并比较它们在体外 在含血清的细胞培养基中的性质与TI 类似地处理涂覆的植入物。 目的2将比较体内 等离子喷涂HA和TI植入物在犬中的性能， 在骨植入物界面、界面 强度和涂层再吸收。 需要检验的假设是：1） HA涂层的表面性质将在体外 孵育，因此将影响它们的体内稳定性; 2）在孵育之前， 加载，等离子喷涂HA和TI涂层的存在将导致 在骨植入物结合强度的增加中， 与未经表面处理的TI表面相比，贴壁;以及3） 在一年的负荷后，反向扭矩和骨的差异 将在等离子喷涂HA和TI植入物之间观察到沉积， 未经处理的TI植入物。 目前临床上常放置种植体 在进行基本实验研究以阐明 重塑机制，可以提高临床适用性。 数据 这项试验性研究所产生的数据，可提供有关医管局的所需资料， 表面性质，提供初步信息的关系 在不同表面的植入物之间，并为未来提供基础 长期的体内临床研究，同时建议最佳表面 最大化植入物稳定性所需的治疗。 这些结果可能 减少植入失败，这在创伤、时间和 钱