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HA AND TI COATINGS ON BONE/IMPLANT INTERACTIONS

HA 和 TI 涂层对骨/种植体相互作用的影响

基本信息

批准号：
2897156
负责人：
JOO L. ONG
金额：
$ 2.18万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-08-01 至 2001-07-31
项目状态：
已结题

项目摘要

DESCRIPTION: Biomaterials surfaces play an important role in the overall implant success. The objectives of this study are: to compare the performance of surface treated Ti implants to non-surface treated Ti implants in relation to bone implant interface and bone strength; and to investigate the long-term impact on bone remodeling as a result of loading the plasma sprayed titanium implants, plasma sprayed HA implants and non-surface treated TI implants. Aim will evaluate in vitro properties of plasma sprayed HA surfaces and compare their in vitro properties in cell culture medium containing serum with that of TI coated implants treated similarly. Aim 2 will compare the in vivo performance in dogs of plasma sprayed HA and TI implants with non- treated TI implants in terms of bone implant interface, interfacial strength, and coating resorption. Hypotheses to be tested are: 1) that the surface properties of HA coatings will be altered following in vitro incubation and thus will affect their in vivo stability; 2) prior to loading, the presence of plasma sprayed HA and TI coatings will result in an increase in bone implant bonding strength an greater bone apposition when compared to non-surface treated TI surfaces; and 3) after one year loading, differences in reverse torque and bone apposition will be observed among plasma sprayed HA and TI implants, and untreated TI implants. At present, implants are often placed clinically prior to the conduct of basic experimental studies elucidating the remodeling mechanisms that may enhance clinical serviceability. Data generated by this pilot study could provide needed information on HA surface properties, provide preliminary information on relationships among the different surfaced implants, and provide a basis for future long-term in vivo clinical studies, while suggesting an optimum surface treatment required for maximum implant stability. These result could reduce implant failures which are costly in terms of trauma, time, and money.

描述：生物材料表面在整体种植成功。本研究的目的是：比较表面处理钛种植体与非表面处理钛种植体的性能对比钛种植体与骨种植体界面和骨强度的关系；和调查对骨重塑的长期影响装载等离子喷涂钛植入物、等离子喷涂HA植入物和非表面处理的 TI 植入物。 Aim 将进行体外评估等离子喷涂 HA 表面的特性及其体外比较含有血清的细胞培养基中的特性与 TI 的特性相同涂层植入物也进行类似处理。目标 2 将比较体内等离子喷涂 HA 和 TI 植入物在狗中的性能经TI处理的种植体在骨种植体界面、界面方面强度和涂层吸收。要检验的假设是：1） HA涂层的表面特性将在体外发生改变孵化，从而影响其体内稳定性； 2) 之前负载，等离子喷涂HA和TI涂层的存在将导致骨植入物结合强度增加，骨量更大与非表面处理的 TI 表面相比时的并置；和 3) 负载一年后，反向扭矩和骨量的差异将在等离子喷涂的 HA 和 TI 植入物中观察到并置，并且未经处理的 TI 植入物。目前临床上常采用种植体植入在进行基础实验研究之前阐明重塑可能增强临床适用性的机制。数据这项试点研究产生的结果可以提供有关医管局的所需信息表面特性，提供关系的初步信息不同表面种植体之间的差异，并为未来提供基础长期体内临床研究，同时提出最佳表面获得最大种植体稳定性所需的治疗。这些结果可以减少因创伤、时间和成本而导致的植入失败钱。