DYNAMICS OF OSCILLATORY NEURONAL CIRCUITS

细胞和突触特性在动力学中的作用研究 以及振荡神经元电路的灵活操作。我们利用的是 甲壳动物体内的两个中央模式产生电路(CPG) 口胃神经节(STG)，这是对它的继续研究 准备工作始于1969年。口胃系统是最多的 目前可用的广泛映射的神经电路。虽然不是 与健康科学直接相关的，它允许我们问基本的 关于振荡电路的设计和功能的问题， 对我们理解运动和感觉回路的启示 脊椎动物的脊髓和脑。 1.突触时间进程在网络动力学中的作用 突触时程对颞叶的贡献 幽门和胃CPG的手术，两个口胃回路 它们的振荡频率相差约10倍。 2.蜂窝属性和网络动态的调制： 分析了活性膜性质的调制鉴定， 单个神经元及其对次回路功能的影响。 3.网络动力学和感觉运动加工的调制：a 感觉运动通路可塑性的研究 口胃细胞和突触特性的调节 马达电路。 这些问题通过交互、电生理、 药理学和计算机建模技术。

A study of the role of cellular and synaptic properties in the dynamic and flexible operation of oscillating neuronal circuits. We make use of two central pattern-generating circuits (CPGs) within the crustacean stomatogastric ganglion (STG),in a continuation of studies of this preparation begun in 1969. The stomatogastric system is the most extensively mapped neural circuit presently available. While not immediately related to health sciences, it allows us to ask basic questions about the design and function of oscillatory circuits, with implications for our understanding of motor and sensory circuits in vertebrate spinal cord and brain. 1. The role of synaptic time course in network dynamics: An assessment of the contribution of synaptic time-course to the temporal operation of the pyloric and gastric CPGs, two stomatogastric circuits that oscillate with about a 10 fold difference in frequency. 2. Modulation of cellular properties and network dynamics: An analysis of the modulation of active membrane properties in identified, single neurons and the consequent effects upon sub-circuit function. 3. Modulation of network dynamics and sensorimotor processing: A study of plasticity in sensorimotor pathways resulting from the modulation of cellular and synaptic properties in the stomatogastric motor circuits. These questions are addressed by interactive, electrophysiological, pharmacological and computer modeling techniques.