MULTISITE PO2 MEASUREMENTS

多站点 PO2 测量

• 批准号: 6123394
• 负责人: Oleg Grinberg
• 金额: $ 1.95万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6123394
• 关键词: Mammalia; biomedical resource; building /facility design /renovation; gas; technology /technique

While in principle EPR imaging can provide a comprehensive description of the distribution of pO2, this approach usually is limited by the sensitivity of EPR measurements. Localized EPR spectroscopy with particulate materials can provide long term measurements of pO2 in tissue at several sites simultaneously. Magnetic field gradients along X-, Y- and Z-axises were used to resolve EPR spectra from several different sites simultaneously. Using rat hearts and tumors with placement of pieces of material at a distance six or more times the size of the pieces themselves (no matter what kind of material is used), multisite measurements of pO2 (up to eight sites) have been carried out. For example, with LiPc crystals of about 0.5mm in size, sites separated by 3mm or more could be readily followed.

虽然在原则上EPR成像可以提供全面的 描述pO2的分布，这种方法通常是 受EPR测量灵敏度的限制。 局域EPR 利用颗粒材料光谱学可以提供长期的 同时在多个部位测量组织中的pO2。 使用沿沿着X、Y和Z轴的磁场梯度， 能同时分辨几个不同位置的EPR谱。 使用大鼠心脏和肿瘤，将材料片放置在 距离六倍或更多的作品本身的大小（不 无论使用何种材料），pO2的多部位测量 (up（8个）已实施。 例如，使用LiPc 尺寸约为0.5mm的晶体，间隔3mm或更大的位点可以 要随时跟进。