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PERCEIVED RISK OF INHERITED SUSCEPTIBILITY TO CANCER

感知到的遗传性癌症易感性风险

基本信息

批准号：
2796962
负责人：
LOIS J LOESCHER
金额：
$ 1.57万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-09-30 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/2796962
关键词：
cancer risk clinical research family genetics human subject neoplasm /cancer genetics oncology nursing

项目摘要

The rapid and continued identification of gene mutations that predisposes people to cancer has led to a better understanding of inherited susceptibility to cancer (ISC). ISC is a high-risk condition for cancer. No studies of risk perception in people with ISC have been published in the nursing literature. No qualitative studies of risk perception in ISC are found in the literature. This proposed research will, therefore, significantly contribute to the overall knowledge base of perceived risk of cancer in adults with ISC. Knowledge of risk perception is important in understanding the decisions people with ISC make concerning genetic testing and strategies for cancer prevention and detection. Once nurses better understand how people with ISC perceive their cancer risk, other critical studies, such as interventions targeting genetic counseling and decision making for genetic testing or studies of nursing care guided by genetic markers of cancer risk, can logically follow. The purpose of this study is to gain understanding of risk perception in ISC. Specific aims are to (1) conduct phenomenology research to identify the essential structure of risk perception in adults with ISC by identifying categories of data and coding data themes for theory building and instrument development; (2) develop a theory-driven preliminary model of perceived risk of cancer in adults with ISC; and (3) develop and test an instrument on the preliminary model to measure risk perception in adults with ISC who are eligible for genetic testing. Qualitative and quantitative approaches will be used for research design and analysis: phenomenology, preliminary model/theory development, and instrumentation.

快速和持续的基因突变识别，人们对癌症的认识使人们更好地理解了遗传性癌症。癌症易感性（ISC）。 ISC是癌症的高风险状况。没有关于ISC患者风险感知的研究发表在护理文献 ISC中没有关于风险认知的定性研究在文献中可以找到。因此，这项研究将显著有助于感知风险的整体知识基础患ISC的成年人的癌症。风险认知的知识很重要在理解ISC患者在遗传方面的决定时，癌症预防和检测的测试和策略。一旦护士更好地了解ISC患者如何看待他们的癌症风险，其他批判性研究，如针对遗传咨询的干预措施，基因检测或护理研究的决策，癌症风险的遗传标记，可以逻辑地遵循。这样做的目的研究的目的是了解ISC的风险认知。具体目标（1）进行现象学研究，以确定通过识别类别来构建成人ISC的风险感知结构数据和编码数据主题的理论建设和仪器发展;（2）发展一个理论驱动的感知的初步模型成年ISC患者的癌症风险;（3）开发和测试一种仪器初步模型，以衡量风险感知的成年人与ISC谁有资格进行基因检测。定性和定量方法将用于研究设计和分析：现象学，初步模型/理论开发和仪器。