A Skin Cancer Prevention Video Intervention for Organ Transplant Recipients

针对器官移植受者的皮肤癌预防视频干预

• 批准号: 7809327
• 负责人: LOIS J LOESCHER
• 金额: $ 7.45万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-29 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7809327
• 关键词: Address; Affect; Attitude; Basal Cell Cancer; Behavior; Behavior Control; Behavioral; Cancer Detection; Cessation of life; Cicatrix; Clinic; Clinical; Cosmetics; Detection; Development; Early Diagnosis; Funding; General Population; Goals; Health Personnel; Heart; Immune system; Immunosuppression; Intention; Intervention; Kidney; Knowledge; Life; Liver; Longevity; Lung; Malignant Neoplasms; Malignant Squamous Cell Neoplasm; Methodology; Methods; Modeling; Morbidity - disease rate; Neoplasm Metastasis; Organ; Organ Transplantation; Outcome; Outpatients; Pamphlets; Pancreas; Patient Self-Report; Personal Behavior; Persons; Pharmacotherapy; Physicians; Play; Prevention; Recurrence; Research; Risk; Role; Screening for Skin Cancer; Self Efficacy; Self-Examination; Skin; Skin Cancer; Skin Carcinoma; Solid; Sun Exposure; Technology; Testing; Therapeutic immunosuppression; Time; Transplant Recipients; Transplantation; UV Radiation Exposure; United States; Work; Writing; base; behavior change; cancer risk; carcinogenesis; comparison group; evidence base; high risk; improved; innovation; melanoma; mortality; novel strategies; post intervention; programs; public health relevance; skin cancer prevention; success; sun protection; tool

DESCRIPTION (provided by applicant): Organ transplant recipients (OTR)-persons receiving donated solid organs such as kidneys, pancreases, livers, lungs, or hearts-are at exceptionally high risk of all types of skin cancer. Increased risk likely results from immune system changes brought on by life-long drug therapy required after transplantation. Sun exposure also plays a role in development of skin cancer. More than 230,000 OTR in the U.S. are up to 250 times more likely to develop skin cancer than the general public. With the long-term success of organ transplantation improving to 90%, more OTR will be at continued risk of skin cancer. Skin cancer (squamous cell cancer, basal cell cancer, or melanoma) has serious outcomes ranging from scarring and cosmetic disfigurement to death. In OTR, skin cancer is highly aggressive and hard to treat; therefore, prevention and detection are critical for improving survival. Behaviors known to lessen skin cancer risk and improve survival of skin cancer are sun protection and skin self-examination. Unfortunately, OTR do not receive adequate information on skin cancer prevention and detection from healthcare providers. The few OTR who have received verbal or written information retain some skin cancer knowledge, but there are only two existing studies of approaches to improve skin cancer prevention/detection behaviors (sun protection, skin examination) in OTR. These approaches were verbal information from physicians and written brochures. With funding from the NCI, we will first develop a new approach: a short video to provide skin cancer prevention and detection information that is tailored to OTR. We will then compare changes in sun protection and skin self-examination behaviors in two groups of OTR (132 total) who recently underwent transplantation and are being followed in outpatient OTR clinics: (1) 66 OTR who view the video plus receive skin cancer general information brochures and (2) 66 OTR who receive the brochures only. We also will evaluate the effect of the video approach on factors known to influence behavior change, specifically attitudes toward skin cancer, intention to engage in sun protection and skin self-examination behaviors, self confidence in performing the behavior, and personal control over doing the behavior. Findings from this study will help healthcare providers to better inform OTR about their high risk of skin cancer and options for risk- reducing behaviors. Findings also will provide more information about factors that may be important in skin cancer prevention and detection behavior change. PUBLIC HEALTH RELEVANCE: Organ transplant recipients (e.g., receiving kidneys, lungs, pancreases, etc.) are at extremely high risk of skin cancer. They receive little information on skin cancer prevention and detection from healthcare providers. We will develop and evaluate a new information tool: a prevention/detection video tailored to these recipients.

描述（由申请人提供）：器官移植接受者(OTR)-接受捐赠实体器官（如肾脏，胰腺，肝脏，肺或心脏）的人-患各种类型皮肤癌的风险非常高。增加的风险可能是由于移植后需要终身药物治疗带来的免疫系统变化。日晒也会导致皮肤癌的发生。在美国，超过23万的OTR患皮肤癌的可能性是普通大众的250倍。随着器官移植的长期成功率提高到90%，更多的OTR将继续面临皮肤癌的风险。皮肤癌（鳞状细胞癌、基底细胞癌或黑色素瘤）有严重的后果，从疤痕和美容毁容到死亡。在OTR中，皮肤癌具有很强的侵袭性，难以治疗；因此，预防和发现对提高生存率至关重要。可以降低皮肤癌风险和提高皮肤癌存活率的行为是防晒和皮肤自检。不幸的是，OTR没有从医疗保健提供者那里得到关于皮肤癌预防和检测的充分信息。少数接受过口头或书面信息的OTR保留了一些皮肤癌知识，但目前仅有两项关于改善OTR皮肤癌预防/检测行为的研究（防晒、皮肤检查）。这些方法是来自医生的口头信息和书面小册子。在NCI的资助下，我们将首先开发一种新方法：用短视频提供针对OTR的皮肤癌预防和检测信息。然后，我们将比较两组（共132名）最近接受移植手术并在门诊接受随访的OTR的防晒和皮肤自我检查行为的变化：(1)66名观看视频并接受皮肤癌一般信息手册的OTR和(2)66名仅接受手册的OTR。我们还将评估视频方法对影响行为改变的已知因素的影响，特别是对皮肤癌的态度，参与防晒和皮肤自检行为的意愿，进行行为的自信，以及对行为的个人控制。这项研究的结果将有助于医疗保健提供者更好地告知OTR他们的皮肤癌高风险和减少风险的行为选择。研究结果还将提供更多关于皮肤癌预防和检测行为改变的重要因素的信息。