TRIMODAL ELECTRODE SYSTEM FOR PALLIDOTOMY & THALAMOTOMY

用于苍白球切开术的三峰电极系统

• 批准号: 2649572
• 负责人: LEE D MARGOLIN
• 金额: $ 29.07万
• 依托单位: FHC, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-15 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2649572
• 关键词: Macaca; Parkinson's disease; basal ganglia; bioengineering /biomedical engineering; biomaterial compatibility; biomedical equipment development; brain electrical activity; brain mapping; clinical research; electronic recording system; experimental brain lesion; human subject; lenticular nucleus; microelectrodes; neurosurgery; stereotaxic techniques; thalamus

DESCRIPTION (Adapted from Applicant's Abstract): Following the appearance of several promising reports in the medical literature, the use of pallidotomy and thalamotomy for treatment of Parkinson's Disease-related movement disorders has steadily increased in the past few years. The resurgence in these two neurosurgical techniques can be attributed to a better understanding of basal ganglia pathophysiology and development of more reliable and accurate stereotactic, microlesioning, and brain mapping techniques. Our goal is to build and test an intracranial microelectrode system which incorporates three key components: (1) a trimodal (i.e., recording, stimulation, lesion) microelectrode coated with biocompatible insulating materials, (2) appropriate electronics for the control of the trimodal microelectrode, and (3) micropositioning elements. By combining recording, stimulation and lesioning functions with bio- compatible technology and materials, the trimodal microrelectrodes will access target brain areas with less damage to healthy tissue. Micro- electrode function will be simplified by integrating each mode into a single control module. The system will include custom-designed micropositioners. This approach will provide a degree of safety, accuracy and facility not currently available by simplifying surgical mapping calculations and minimizing component switching error. Offering all these features in a single package will allow its pricing to be very competitive and make its clinical use more cost effective. PROPOSED COMMERCIAL APPLICATION: Proposed commercial application not available.

描述（改编自申请人的摘要）：遵循外观 医学文献中一些有希望的报告中，使用 苍白球切开术和丘脑切开术治疗帕金森病相关疾病 过去几年，运动障碍稳步增加。这 这两种神经外科技术的复兴可归因于 更好地了解基底神经节的病理生理学和发育 更可靠、更准确的立体定向、微损伤和脑图绘制 技术。我们的目标是构建并测试颅内微电极 该系统包含三个关键组成部分：（1）三模态（即 记录、刺激、病变）微电极涂有生物相容性 绝缘材料，（2）适当的电子设备用于控制 三峰微电极，以及(3)微定位元件。 通过将记录、刺激和损伤功能与生物相结合 兼容的技术和材料，三峰微电极将 进入目标大脑区域，对健康组织的损害较小。微- 通过将每种模式集成到一个 单一控制模块。该系统将包括定制设计的 微定位器。这种方法将提供一定程度的安全性、准确性 以及目前无法通过简化手术测绘获得的设施 计算并最大限度地减少元件切换误差。提供所有这些 单一封装中的功能将使其定价非常有竞争力 并使其临床使用更具成本效益。 拟议的商业应用： 拟议的商业应用不可用。