Polymodal Electrode System for Intracranial Applications

描述(申请人提供)：该项目旨在开发一种可植入的多模式电极系统(PES)，可用于获取体积电生理数据，用于优化立体定向神经外科干预措施，如射频消融和脑深部刺激。这类干预措施正在迅速涌现，作为各种顽固性神经疾病的治疗方法，包括运动障碍、疼痛和癫痫。越来越多的电生理技术，如显微记录和微微和宏观刺激，被用作从CT和/或MRI扫描得出的基于解剖的靶点选择的辅助工具。 本文提出的工作将测试开发多模式电极阵列的可行性，该阵列具有用户可选择的、单独可控的小到足以既用作记录单个单位的微电极又用作微刺激部位的元件。 第一阶段的初始工作将包括调查制造PES阿尔法原型所需的设计和制造参数(即电极材料、绝缘类型、微线配置、涂层)。从中心芯轴以受控和可重复的方式挤出微丝的可行性也将在第一阶段得到确认，从第一阶段工作中获得的信息将在第二阶段用于制造用于动物试验的PES Beta原型。 建议的商业应用：最近，各种功能性神经外科方法，如射频消融或慢性脑深部刺激，用于治疗运动障碍、癫痫和顽固性疼痛，取得了成功，使这些技术在其他医疗选择不合适的情况下成为可行的替代方案。这些程序的一个完整的PRT是使用颅内神经记录和刺激技术进行靶点定位。随着每年进行更多的功能性神经外科手术，对新的、创新的电极技术的需求越来越大，这种技术更安全，并为神经外科医生提供更好的诊断和治疗能力。

DESCRIPTION (provided by applicant): This project is aimed at developing an implantable polymodal electrode system (PES) that could be used to obtain volumetric electrophysiological data useful for the optimization of stereotactically targeted neurosurgical interventions such as RF ablation and deep brain stimulation. Such interventions are rapidly emerging as treatments for a variety of intractable neurological conditions, including movement disorders, pain and epilepsy. Increasingly electrophysiological techniques such as microrecording and micro- and macrostimulation are employed as an adjunct to anatomically based target selection derived from CT and/or MRI scans. The work proposed herein would test the feasibility of the development of an array of polymodal electrodes with user-selectable, individually controllable elements small enough to function as both microelectrodes for recording single units as well as microstimulation sites. Initial Phase I work will include an investigation of the necessary design and fabrication parameters, (i.e., electrode materials, insulation types, microwire configuration, coatings) in order to manufacture a PES alpha prototype. The feasibility of extruding microwires from a central core shaft in a controlled and reproducible manner will also be confirmed during Phase I. Information gained from Phase I work will then be used in Phase II to fabricate PES beta prototypes for use in animal testing. PROPOSED COMMERCIAL APPLICATION: The recent success of various functional neurosurgical approaches like radiofrequency ablation or chronic deep brain stimulation for the treatment of movement disorders, epilepsy and intractable pain has established these techniques as viable alternatives when other medical options are unsuitable. An integral prt of these procedures is the use of intracranial neural recording and stimulation techniques for target localization. As more functional neurosurgical procedures are performed each year, there is a growing need for new and innovative electrode technology that is safer and provides the neurosurgeon with better diagnostic and therapeutic capabilities.