Polymodal Electrode System for Intracranial Applications

用于颅内应用的多模态电极系统

• 批准号: 6549975
• 负责人: LEE D MARGOLIN
• 金额: $ 10万
• 依托单位: FHC, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6549975
• 关键词: biomaterial compatibility; biomaterial development /preparation; electrodes; electronic recording system; electronic stimulator; electrophysiology; implant; medical implant science; nervous system prosthesis; neurosurgery; technology /technique development

DESCRIPTION (provided by applicant): This project is aimed at developing an implantable polymodal electrode system (PES) that could be used to obtain volumetric electrophysiological data useful for the optimization of stereotactically targeted neurosurgical interventions such as RF ablation and deep brain stimulation. Such interventions are rapidly emerging as treatments for a variety of intractable neurological conditions, including movement disorders, pain and epilepsy. Increasingly electrophysiological techniques such as microrecording and micro- and macrostimulation are employed as an adjunct to anatomically based target selection derived from CT and/or MRI scans. The work proposed herein would test the feasibility of the development of an array of polymodal electrodes with user-selectable, individually controllable elements small enough to function as both microelectrodes for recording single units as well as microstimulation sites. Initial Phase I work will include an investigation of the necessary design and fabrication parameters, (i.e., electrode materials, insulation types, microwire configuration, coatings) in order to manufacture a PES alpha prototype. The feasibility of extruding microwires from a central core shaft in a controlled and reproducible manner will also be confirmed during Phase I. Information gained from Phase I work will then be used in Phase II to fabricate PES beta prototypes for use in animal testing. PROPOSED COMMERCIAL APPLICATION: The recent success of various functional neurosurgical approaches like radiofrequency ablation or chronic deep brain stimulation for the treatment of movement disorders, epilepsy and intractable pain has established these techniques as viable alternatives when other medical options are unsuitable. An integral prt of these procedures is the use of intracranial neural recording and stimulation techniques for target localization. As more functional neurosurgical procedures are performed each year, there is a growing need for new and innovative electrode technology that is safer and provides the neurosurgeon with better diagnostic and therapeutic capabilities.

描述（由申请人提供）：本项目旨在开发一种植入式多模态电极系统（PES），该系统可用于获得可用于优化立体定向靶向神经外科干预（如射频消融和脑深部电刺激）的体积电生理数据。这种干预措施正在迅速成为各种难治性神经系统疾病的治疗方法，包括运动障碍、疼痛和癫痫。越来越多的电生理技术，如微记录和微刺激和宏刺激，作为辅助解剖学为基础的目标选择来自CT和/或MRI扫描。 本文提出的工作将测试开发多模态电极阵列的可行性，该多模态电极阵列具有用户可选择的、单独可控的元件，该元件足够小以用作用于记录单个单元以及微刺激部位的微电极。 初始阶段I工作将包括必要的设计和制造参数的调查（即，电极材料、绝缘类型、微丝配置、涂层），以制造PES alpha原型。还将在第I阶段期间确认以受控和可再现的方式从中心芯轴挤出微导丝的可行性。从第一阶段工作中获得的信息将用于第二阶段，以制造用于动物试验的PES β原型。 拟定商业应用：最近成功的各种功能性神经外科方法，如射频消融或慢性脑深部电刺激治疗运动障碍，癫痫和顽固性疼痛，建立了这些技术作为可行的替代方案时，其他医疗选择是不合适的。 这些手术的一个组成部分是使用颅内神经记录和刺激技术进行靶定位。 随着每年进行更多的功能性神经外科手术，对更安全并为神经外科医生提供更好的诊断和治疗能力的新型创新电极技术的需求日益增长。