TRIMODAL ELECTRODE SYSTEM FOR PALLIDOTOMY & THALAMOTOMY

用于苍白球切开术的三峰电极系统

• 批准号: 2892347
• 负责人: LEE D MARGOLIN
• 金额: $ 45.93万
• 依托单位: FHC, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-15 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2892347
• 关键词: Macaca; Parkinson's disease; basal ganglia; bioengineering /biomedical engineering; biomaterial compatibility; biomedical equipment development; brain electrical activity; brain mapping; clinical research; electronic recording system; experimental brain lesion; human subject; lenticular nucleus; microelectrodes; neurosurgery; stereotaxic techniques; thalamus

DESCRIPTION (Adapted from Applicant's Abstract): Following the appearance of several promising reports in the medical literature, the use of pallidotomy and thalamotomy for treatment of Parkinson's Disease-related movement disorders has steadily increased in the past few years. The resurgence in these two neurosurgical techniques can be attributed to a better understanding of basal ganglia pathophysiology and development of more reliable and accurate stereotactic, microlesioning, and brain mapping techniques. Our goal is to build and test an intracranial microelectrode system which incorporates three key components: (1) a trimodal (i.e., recording, stimulation, lesion) microelectrode coated with biocompatible insulating materials, (2) appropriate electronics for the control of the trimodal microelectrode, and (3) micropositioning elements. By combining recording, stimulation and lesioning functions with bio- compatible technology and materials, the trimodal microrelectrodes will access target brain areas with less damage to healthy tissue. Micro- electrode function will be simplified by integrating each mode into a single control module. The system will include custom-designed micropositioners. This approach will provide a degree of safety, accuracy and facility not currently available by simplifying surgical mapping calculations and minimizing component switching error. Offering all these features in a single package will allow its pricing to be very competitive and make its clinical use more cost effective. PROPOSED COMMERCIAL APPLICATION: Proposed commercial application not available.

描述（改编自申请人的摘要）： 在医学文献中的几份有希望的报告中，使用 苍白球和丘脑切开术治疗帕金森病相关性 运动障碍在过去几年中稳步增加。的 这两种神经外科技术的复兴可以归因于 更好地了解基底神经节的病理生理学和 更可靠和准确的立体定向、微损伤和脑标测 技术.我们的目标是建立和测试一个颅内微电极 该系统包括三个关键部件：（1）三模式（即， 记录、刺激、损伤）微电极 绝缘材料，（2）适当的电子控制， 三峰微电极，和（3）微定位元件。 通过将记录、刺激和损伤功能与生物 兼容的技术和材料，三峰微电极将 进入目标大脑区域，对健康组织的损伤较小。微- 电极功能将通过将每个模式集成到 单个控制模块。该系统将包括定制设计的 微型定位器这种方法将提供一定程度的安全性、准确性 通过简化外科标测， 计算和最小化元件切换误差。提供所有这些 在一个单一的包功能将使其价格非常有竞争力 并使其临床使用更具成本效益。 拟定商业应用： 未提供拟议的商业应用。