TRIMODAL ELECTRODE SYSTEM FOR PALLIDOTOMY & THALAMOTOMY

在医学界出现了几份有希望的报告之后， 文献，使用苍白球和丘脑切开术治疗 帕金森病相关的运动障碍 在过去的几年里一直在稳步增长。这些国家的复兴 两种外科技术的发展部分归因于 更可靠的微损伤系统和更精确的大脑绘图 技术.我们的目标是研制一种颅内微电极 该系统将包括三个关键组成部分：1.）三模态（即， 记录、刺激、损伤）微电极 绝缘材料，2.）适当的电子控制 三峰微电极，和3.）微定位元件通过组合 具有生物相容性的记录、刺激和损伤功能 技术和材料，三峰微电极将达到目标 对健康组织损伤较小的大脑区域。微电极功能 将通过将每种模式集成到单个控制模块中来简化。 该系统将包括定制设计的微定位器。这种方法 将提供一定程度的安全性和准确性， 简化手术标测计算并最小化组件 切换错误在一个软件包中提供所有这些功能， 使其价格极具竞争力，并使其临床用途更加广泛。 成本效益。 拟定商业应用： 最近苍白球切开术和丘脑切开术已重新成为有效的 帕金森病相关运动障碍的治疗。是 据估计，35万美国人可能会从这些程序中受益。的 开发了一种集成颅内电极系统， 准确和更容易使用比目前的技术有很大的商业 在这一PD患者亚群中的治疗潜力。我们的目标是 生产一种价格适中的系统， 缩短手术时间，减少 减少并发症，降低手术和术后护理成本。

Following the appearance of several promising reports in the medical literature, the use of pallidotomy and thalamotomy for the treatment of Parkinson's Disease-related movement disorders has been steadily increasing over the past few years. The resurgence in these two surgical techniques can be attributed in part to the development of more reliable microlesioning systems and more accurate brain mapping techniques. Our goal is to develop a single intracranial microelectrode system that will incorporate three key components: 1.) a trimodal (i.e., recording, stimulation, lesion) microelectrode coated with biocompatible insulating materials, 2.) appropriate electronics for the control of the trimodal microelectrode, and 3.) micropositioning elements. By combining recording, stimulation and lesioning functions with biocompatible technology and materials, the trimodal microelectrode will access target brain areas with less damage to healthy tissue. Microelectrode function will be simplified by integrating each mode into a single control module. The system will Include custom-designed micropositioners. This approach will provide a degree of safety and accuracy not currently available by simplifying surgical mapping calculations and minimizing component switching error. Offering all these features in a single package will allow its pricing to be very competitive and make its clinical use more cost effective. PROPOSED COMMERCIAL APPLICATION: Recently pallidotomy and thalamotomy have reemerged as effective treatments of Parkinson's Disease-related movement disorders. It is estimated that 350,000 Americans may benefit from these procedures. The development of an integrated intracranial electrode system that is highly accurate and easier to use than current technologies has great commercial potential for treatment in this subpopulation of PD sufferers. Our goal is to produce a moderately-priced system that will damage less healthy tissue and shorten the duration of the procedures, resulting in fewer complications and reducing surgical and post-operative care costs.