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CATHETER FOR SIMULATANEOUS MAPPING AND LASER ABLATION

用于同步标测和激光烧蚀的导管

基本信息

批准号：
2668746
负责人：
EDWARD L SINOFSKY
金额：
$ 36.79万
依托单位：
CARDIOFOCUS, INC.
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-03-01 至 2000-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2668746
关键词：
biomedical equipment development disease /disorder model dogs electrodes electrophysiology heart catheterization laser therapy lasers myocardium nonhuman therapy evaluation photocoagulation therapy tachycardia

项目摘要

Various energy sources have been used to "ablate" (coagulate) myocardium responsible for initiating or sustaining ventricular tachycardia. We propose to further refine a catheter system that initially detects the location responsible for the arrhythmia, and subsequently treats the area with an interstitial dose of diffused laser diode energy. Lasers have not been widely used to treat arrhythmias due to the high cost and complexity of the laser source, and lack of a laser catheter capable of creating a reproducible tissue response without directly radiating blood, forming coagulum or perforating the heart. The proposed technologies overcome these deficiencies. Experiments are designed to enhance delivery and facilitate catheter positioning, add safety features, further understand wavelength and dosimetry effects, improve mapping capability, and enhance deployment ergonomics. The catheter designs will be refined, fabricated, and tested to allow electrophysiologic monitoring, with subsequent ablation, when the source of tachycardia is located. This coagulation will be induced interstially by inserting a diffusing fiber intramyocardially. The diffusing tips spread the light in a cylindrical pattern which has advantages over bare end fibers currently being used. Recent innovations have enabled us to make reproducible, clinically relevant thermal lesions, percutaneously in a canine model, providing proof of principle of the applicability of the proposed technique.

各种能源已用于“消融”（凝固）心肌负责引发或维持室性心动过速。我们建议进一步改进导管系统，的负责心律失常的位置，并随后治疗该地区具有扩散的激光二极管能量的间隙剂量。激光尚未被广泛用于治疗心律失常，高激光源的成本和复杂性，以及缺乏激光器导管能够产生可再现的组织反应，辐射血液形成凝块或刺穿心脏的提出技术克服了这些缺陷。实验的目的是提高交付和促进导管定位，增加安全功能，进一步了解波长和剂量学效应，提高绘图能力，并增强部署人体工程学将对导管设计进行改进、制造和测试，允许当出现电生理监测时，进行后续消融源心动过速的位置这种凝固会被诱导在精神上通过在心肌内插入弥散纤维。漫射提示以圆柱形图案传播光，裸目前正在使用的光纤。最近的创新使我们能够在临床上相关热损伤，在犬模型中持续存在，提供所提出的技术的适用性的原理证明。