PHOTONIC TREATMENT OF ATRIAL ARRHYTHMIA

房性心律失常的光子治疗

• 批准号: 6015683
• 负责人: EDWARD L SINOFSKY
• 金额: $ 9.99万
• 依托单位: CARDIOFOCUS, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6015683
• 关键词: arrhythmia; biomedical equipment development; catheterization; fiber optics; goats; laser therapy; radiation dosage

Current treatment modalities include drugs and surgery, and several other therapies are in clinical evaluation including RF, cryoablation and microwave ablation and implantable defibrillators; however, all are considered sub-optimal. Our proposed work focuses on the development of a photonic based ablation system designed for use in the three areas targeted in the ablation of atrial arryhthmias. Diffusing tip designs will be tested for their potential to ablate atrial flutter, and atrial fibrillation by studying the formation of continuous linear lesions with energy from a high power diode laser system. Catheter systems will be proposed and tested, with the goal of creating linear lesions in one single application of energy, therein significantly reducing procedure times. Experiments are designed to explore the dosimetry of photonic energy application to the three different tissue types relevant to the ablation; design and test a novel deflectable catheter to create ablation lines near the vena cava and atrial roof via percutaneous delivery of photonic energy; and design and test a newly conceived 'halo' shaped optical diffuser for ablation in pulmonary veins. PROPOSED COMMERCIAL APPLICATIONS: Atrial fibrillation is the most common sustained cardiac rhythm disorder and is estimated to afflict 2.5 MM people in the US and over 5 MM people worldwide. Non-surgical treatment of atrial fibrillation and atrial flutter offers a significant opportunity to address this huge market need. Lightstic diffusers are capable of producing continuous linear lesions necessary to ablate multi-reentrant arrhythmia. This new minimally invasive photonic based procedure offers several potential advantages over other energy sources such as, radio frequency, cryo-ablation or microwave.

目前的治疗方式包括药物和手术，其他几种治疗方法正在临床评估中，包括射频、冷冻消融和微波消融以及植入式消融器;然而，所有这些都被认为是次优的。我们提出的工作重点是开发一种基于光子的消融系统，设计用于心房心律失常消融的三个目标区域。将通过研究使用高功率二极管激光系统能量形成的连续线性损伤，测试弥散头端设计消融房扑和房颤的潜力。将提出并测试导管系统，目标是在单次能量应用中创建线性损伤，从而显著缩短手术时间。实验旨在探索光子能量应用于与消融相关的三种不同组织类型的剂量学;设计和测试一种新型的可偏转导管，以通过经皮输送光子能量在腔静脉和心房顶部附近创建消融线;并设计和测试一种新构思的用于肺静脉消融的“晕”形光扩散器。拟议的商业应用：心房颤动是最常见的持续性心律失常，估计在美国有250万人受其折磨，在全球有超过500万人受其折磨。房颤和房扑的非手术治疗为满足这一巨大的市场需求提供了重要机会。Lightstic扩散器能够产生消融多折返性心律失常所需的连续线性损伤。这种新的基于光子的微创手术提供了优于其他能量源（例如射频、冷冻消融或微波）的几个潜在优势。