X RAY GUIDED LASER THERAPY SYSTEM FOR BREAST CANCER

X 射线引导乳腺癌激光治疗系统

• 批准号: 2646457
• 负责人: EDWARD L SINOFSKY
• 金额: $ 9.95万
• 依托单位: CARDIOFOCUS, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2646457
• 关键词: X ray; biomedical equipment development; breast neoplasms; clinical biomedical equipment; laser therapy; mammography; method development; neoplasm /cancer photoradiation therapy; photocoagulation therapy; stereotaxic techniques; swine

We seek to develop a technique to treat breast cancer tumors in a minimally invasive way. The tumors would be eradicated using laser energy to photocoagulate the lesion through an incisionless interstitial approach. This approach will be enhanced by the capabilities of a high resolution X-ray, stereotactically guided, system that can accurately locate the lesion in 3 dimensions and deliver a trocar/cannulae to that exact location. After delivery of a specially designed laser energy transparent cannulae to the treatment site, laser energy will be uniformly diffused to treat the lesion with hyperthermia/coagulation. Laser probes will be miniaturized to minimize insertion trauma. This is a technologic approach to concern facing the 184,000 U.S. women yearly, with breast cancer, who live in dread of disfigurement from mastectomy and lumpectomy. We propose to: design, build and test a laser energy diffusing system capable of being stereotactically delivered to safely deliver the energy needed to coagulate clinically relevant tumors, examine the feasibility of monitoring the extent of the coagulated volume with the high resolution X-ray system already in use, and test the combined systems in an ex-vivo- and in-vivo model. PROPOSED COMMERCIAL APPLICATION The focus on the issue of breast cancer, from the mammogram to the possibility of mastectomy or lumpectomy, is one of today's highest health care concerns. A system that could locate and simultaneously treat breast cancer tumors in a minimally invasive way would have huge commercial application.

我们寻求开发一种技术来治疗乳腺癌肿瘤， 微创的方式。 肿瘤将用激光根除 能量通过无切口光凝病变 间质方法。 这种方法将得到加强， 高分辨率X射线立体定向引导系统的能力 它可以在三维空间中准确定位病变， 将套管针/插管插入准确位置。 在交付一个特别的 设计的激光能量透明套管，用于治疗部位，激光 能量将被均匀地扩散以治疗损伤 热疗/凝血。 激光探针将小型化， 插入创伤。 这是一种技术方法来解决184，000名美国妇女所面临的问题 每年，与乳腺癌，谁生活在恐惧的毁容， 乳房切除术和肿块切除术。 我们建议：设计、建造和测试一个 可立体定向的激光能量扩散系统 安全输送临床凝血所需的能量 相关的肿瘤，检查监测的范围的可行性 凝固体积与已在使用的高分辨率X射线系统， 并在离体和体内模型中测试组合的系统。 建议的商业应用 关注乳腺癌问题，从乳房X光检查到 乳房切除术或肿块切除术的可能性，是当今最高的 医疗保健问题。 一个可以定位并同时 以微创的方式治疗乳腺癌肿瘤， 商业应用。

项目成果

Thermal analysis of laser interstitial thermotherapy in ex vivo fibro-fatty tissue using exponential functions.

使用指数函数对离体纤维脂肪组织进行激光间质热疗的热分析。

• DOI: 10.1088/0031-9155/49/9/002
• 发表时间: 2004
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: SalasJr,Nelson;Manns,Fabrice;Milne,PeterJ;Denham,DavidB;Minhaj,AhmedM;Parel,Jean-Marie;Robinson,DavidS
• 通讯作者: Robinson,DavidS