DIFFUSING TIPS FOR LASER THERAPY

激光治疗的扩散头

• 批准号: 2100915
• 负责人: EDWARD L SINOFSKY
• 金额: $ 38.87万
• 依托单位: CARDIOFOCUS, INC.
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-02-01 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2100915
• 关键词: biomedical equipment development; dogs; fiber optics; human tissue; laser therapy; nonhuman therapy evaluation; photocoagulation therapy; radiation dosage

DESCRIPTION: (Adapted from applicant's abstract) To date, practitioners have had few choices for fiberoptic systems that can deliver high power laser radiation in a distributed pattern to remote anatomical locations. A new generation of diffusing tips has been designed, and tested, in in vitro and in vivo studies, that will provide exciting new optical tools for minimally invasive medicine. The inherent flexibility of the design allows us to tailor their characteristics to optimize their emission patterns and mechanical properties to make them suitable to a wide range of applications in photomedicine. The ability to distribute high laser power (5-100 watts) uniformly, in a cylindrical geometry, in lengths that vary from 5-35 mm., will open new vistas in the treatment of benign and malignant disease. Equally important is the ability to uniformly distribute low or moderate laser power through small diameter (<400 um) diffusers, as remote and tortuous treatment sites can be accessed. Specifically, these tips have applications in photocoagulation, and in photodynamic and/or hyperthermia therapy. Further in vitro, preclinical animal and clinical studies are proposed to optimize the device geometry, dosimetry, as well as demonstrate the safety and efficacy of the systems for treatment of prostatic diseases, liver cancer, and in photodynamic therapies. Additionally, an extra feature will be added by implementing an infrared detecting shutoff circuit.

描述：（改编自申请人的摘要）迄今为止，从业者 对于能够提供高功率的光纤系统几乎没有选择 激光以分布式模式辐射到远程解剖位置。 新一代扩散头已在 2019 年设计并测试 体外和体内研究，将提供令人兴奋的新光学工具 用于微创医学。 设计固有的灵活性 允许我们定制它们的特性以优化它们的排放 图案和机械性能使其适用于广泛的范围 光医学中的应用。 能够均匀分布高激光功率（5-100 瓦） 将打开长度为 5-35 毫米的圆柱形几何形状 良性和恶性疾病治疗的新前景。 同样 重要的是均匀分布低或中激光的能力 通过小直径（<400 um）扩散器供电，因为距离遥远且曲折 可以访问治疗地点。 具体来说，这些技巧有 在光凝、光动力和/或中的应用 热疗。 进一步的体外、临床前动物和临床 建议进行研究以优化设备几何形状、剂量测定以及 证明系统治疗的安全性和有效性 前列腺疾病、肝癌和光动力疗法。 此外，通过实施红外线将添加额外的功能 检测关断电路。