MRI OF CORONARY COLLATERALS

冠状动脉冠状动脉 MRI

• 批准号: 2471559
• 负责人: JUSTIN D PEARLMAN
• 金额: $ 25.2万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-15 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2471559
• 关键词: angiography; blood flow measurement; blood volume; cardiovascular disorder chemotherapy; cardiovascular disorder diagnosis; cardiovascular imaging /visualization; collateral circulation; computed axial tomography; coronary artery; coronary occlusion /thrombosis; diagnosis design /evaluation; diagnosis quality /standard; early diagnosis; growth factor; heart function; heart ventricle; immunocytochemistry; magnetic resonance imaging; microcapsule; myocardium; nonhuman therapy evaluation; postmortem; swine; tissue /cell culture; vascular resistance

DESCRIPTION (Adapted from applicant's abstract): In the United States, nearly half of all deaths in the adult population are due to cardiovascular disease. Coronary collateralization is a natural bypass system which is currently the target for new therapies to prevent myocardial damage from heart attack. This investigation will develop a new and advanced diagnostic MRI tool to detect early coronary collateralization and monitor the effect of a course of treatment to stimulate coronary collateralization. Recent studies have shown that certain growth factors increase the collateral circulation in chronic ischemia. In addition, the investigators have shown, using new MRI methods, that a course of growth factor treatment can achieve sufficient increase in collateralization to preserve normal cardiac function and avoid heart damage when a coronary artery occludes. Currently, there is no clinical test available to quantify the extent of collateralization before coronary occlusion occurs. Now, the medical treatment to stimulate coronary collateral development is possible, so a noninvasive clinical test to monitor and evaluate the treatment benefit is required. The investigators have developed a collateral-sensitized MRI method. In this investigation, they will compare the assessment of collateralization by collateral-sensitized MRI with assessment by invasive measures. The study will clarify how well early coronary collateralization can be characterized and monitored by the new collateral-sensitized MRI. It will examine the ability to detect changes in collateralization with time and will clarify associated physiologic changes. It will examine potentially confounding factors insufficiency collateral flow distribution. The collateral-sensitized MRI methods will be optimized for clinical application. This proposal is to validate the accuracy of collateral-sensitized MRI, study its ability to monitor growth factor effectiveness in an animal model, predict the functional benefits and further develop the new diagnostic tools to enable their clinical use with the new medical therapies to prevent myocardial damage from heart attacks.

描述（根据申请人的摘要改编）：在美国， 成年人口中所有死亡的几乎一半是由于心血管造成的 疾病。 冠状动脉抵押是一种自然旁路系统 目前，新疗法的目标是防止心肌损伤 心脏病发作。 这项调查将开发新的高级诊断 MRI工具检测早期冠状动脉抵押并监测效果 刺激冠状动脉抵押的治疗过程。 最近的 研究表明，某些生长因子会增加抵押品 慢性缺血中的循环。 此外，调查人员表明， 使用新的MRI方法，生长因子治疗的过程可以实现 足够增加抵押品以保持正常心脏功能 并避免冠状动脉阻塞时心脏损伤。 目前，有 没有可用的临床测试来量化抵押的程度 在发生冠状动脉闭塞之前。 现在，刺激的医疗 冠状动脉附带发展是可能的，因此无创临床测试 需要监视和评估治疗益处。 这 研究人员已经开发了副敏感的MRI方法。 在这项调查中，他们将比较抵押品的评估 通过对侵入性措施评估的抵押敏感的MRI。 这 研究将阐明早期冠状动脉抵押品的表现如何 由新的附带敏感的MRI进行表征和监测。 会 检查随时间和时间检测抵押品变化的能力和 将澄清相关的生理变化。 它将可能检查 混杂因素功能不全侧支流分布。 这 抵押敏感的MRI方法将用于临床 应用。 该建议是验证附带敏感的MRI的准确性， 研究其在动物模型中监测生长因素有效性的能力， 预测功能好处并进一步开发新的诊断工具 为了使新医疗疗法的临床使用以防止 心脏病发作会损害心肌。