Core--Human MR imaging

核心--人体MR成像

• 批准号: 6584689
• 负责人: JUSTIN D PEARLMAN
• 金额: $ 21.93万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6584689
• 关键词: angiogenesis; bioimaging /biomedical imaging; biomedical facility; cardiovascular function; clinical research; collateral circulation; heart circulation; heart disorder diagnosis; heart function; human subject; magnetic resonance imaging; microcirculation; swine

The large bore MRI Core laboratory of this SCOR will provide comprehensive services to the participating investigators regarding quantitative assessment of impaired blood delivery, new vessel development, and functional consequences in large animal (pig) model of angiogenesis and in clinical trials. The primary categories of support will include: 1: in vivo assessment of blood delivery to heart tissue, sensitive to changes over time and response to treatment; 2: in vivo assessment of cardiovascular function, including motion- tracking, partial-volume corrected measures of wall thickness changes, centrifugal endocardial excursion, and ejection fraction; 3: in vivo assessment of microvascular collateral development, based on a new imaging method developed and validated in our laboratory by ex vivo CT, microspheres and histology. The Core will be responsible for MRI scheduling, imaging protocols, image acquisition, quality assurance, image data management and measurements blinded to treatment status, of blood arrival, wall function, and new vessel development in patients and large animal models of ischemic heart disease.

该SCOR的MRI核心实验室的大孔将为参与研究人员提供有关血管生成和临床试验中大动物（PIG）模型的血液递送，新血管发展和功能后果的定量评估的全面服务。支持的主要类别将包括：1：在体内对血液递送到心脏组织的评估，对随着时间的变化和对治疗的反应敏感； 2：体内评估心血管功能，包括运动跟踪，部分体积校正了壁厚变化的措施，离心心内膜移动和射血分数； 3：基于在我们的实验室中通过离体CT，微球和组织学在我们的实验室中开发和验证的新成像方法的微血管副作用开发的体内评估。核心将负责MRI调度，成像方案，图像获取，质量保证，图像数据管理和对治疗状态的测量，血液到来，壁功能，壁功能和新血管的发育以及缺血性心脏病的大型动物模型。