BRACHIAL ARTERY VASOREACTIVITY

肱动脉血管反应性

• 批准号: 2685522
• 负责人: JOHN R CROUSE
• 金额: $ 21.52万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-17 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2685522
• 关键词: aging; atherosclerosis; cardiovascular disorder diagnosis; clinical research; coronary disorder; diagnosis design /evaluation; disease /disorder proneness /risk; gender difference; human old age (65+); human subject; longitudinal human study; mathematical model; myocardial infarction; racial /ethnic difference; vascular endothelium; vasodilation

DESCRIPTION: (Adapted from Investigator's Abstract) Abnormalities of arterial vasoreactivity have been linked to a multitude of cardiovascular disease risk factors, have been shown to improve with risk factor intervention, and have been associated with prevalent coronary artery disease. Many of these observations have used as the index of vasoreactivity flow-mediated arterial dilation, a non-invasively measured parameter uniquely suited for epidemiologic investigation; this index, however, has not been tested for its association with incident coronary heart disease (CHD). Previously flow-mediated brachial arterial vasoreactivity has been quantified by a single measurement of arterial dilation measured at a fixed point in time following increase of blood flow. Bowman Gray has developed a new method for quantifying brachial artery vasoreactivity that promises to markedly enhance the informativeness of the procedure by identifying not only the maximum artery responsivity but also the time to maximum response. The proposed study will augment data already being collected in the Cardiovascular Health Study (CHS), a multicenter NIH funded population based study of risk factors and their relation to prevalent and incident symptomatic CHD and other vascular disease as well as subclinical vascular disease (e.g., asymptomatic atherosclerosis). The CHS population was initially age 65 and older (1989-1990), and will undergo its 9th yearly examination from June, 1997 through June, 1998 (n=about 3000 participants). The investigators propose to add a measure of flow-mediated brachial artery vasoreactivity to this examination. Analysis will quantify associations between flow-mediated brachial artery vasoreactivity and incident CHD over 3 years. Also of interest will be associations of vasoreactivity with cardiovascular disease risk factors and with other indices of subclinical vascular disease. The investigators state that it is likely that flow-mediated brachial artery vasoreactivity, since it provides an index of a different dimension of vascular disease than those provided by B-mode ultrasound or ankle-arm index, will be independently related to incident CHD.

描述：（改编自研究者摘要） 动脉血管反应性与许多心血管疾病有关， 疾病的危险因素，已被证明是改善与风险因素 介入治疗，并已与流行的冠状动脉 疾病 其中许多观察结果被用作 血管反应性血流介导的动脉扩张，一种非侵入性测量 唯一适合流行病学调查的参数;该指数， 然而，还没有测试其与冠状动脉事件的相关性， 心脏病（CHD）。 既往血流介导肱动脉 血管反应性已经通过对动脉的单次测量来量化。 在血流增加后的固定时间点测量的扩张。 Bowman Gray开发了一种新的方法来量化肱动脉 血管反应性，承诺显着提高的信息性， 不仅识别最大动脉反应性， 最大响应时间。 拟议中的研究将增加数据已经 NIH多中心心血管健康研究（CHS）正在收集数据 受资助的基于人群的风险因素及其与 流行的和偶发的有症状的CHD和其他血管疾病，以及 亚临床血管疾病（例如，无症状动脉粥样硬化）。 社区卫生服务 人口最初年龄为65岁及以上（1989-1990年）， 1997年6月至1998年6月的第9次年度检查（n=约3000 参与者）。 研究人员建议增加一种测量流量介导的 肱动脉的血管反应性。 分析将量化 血流介导的肱动脉血管反应性与 3年以上CHD事件。 同样令人感兴趣的是， 血管反应性与心血管疾病危险因素和其他 亚临床血管疾病的指数。 调查人员表示， 可能是血流介导的肱动脉血管反应性，因为它提供了 血管疾病的不同维度的指数，而不是由 B超或踝臂指数，将独立相关 CHD事件。