RGULATION OF CYCLIC GMP PHOSPHODIESTERASE BY GZ
广州市对环GMP磷酸二酯酶的规定
基本信息
- 批准号:6018420
- 负责人:
- 金额:$ 3.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-08-01 至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Much progress has been made in our understanding of how cells transmit
external signals via specific cell surface receptors to internal
targets. Receptor binding initiates intracellular signaling pathways,
often through the activation of heterotrimeric G-proteins, eventually
leading to a specific cellular response. Gz is one such heterotrimeric
G-protein that exhibits unique biochemical features and limited tissue
distribution. Although initial characterization of Gz has provided
insight into the biochemical characterization of the protein, the
downstream target(s) of Gz remain undefined. Preliminary studies
utilizing the yeast two-hybrid system suggest that Gzalpha may possibly
interact with the gamma subunit of cyclic GMP phosphodiesterase. G-
protein regulation of phosphodiesterases has not been described outside
sensory tissues, but recent identification of both Gz and
phosphodiesterase gamma in various regions of the brain supports the
view that this may occur. We postulate that phosphodiesterase gamma is
a natural effector for Gz. Both in vitro studies and studies in intact
cells will be conducted to determine whether phosphodiesterase gamma and
Gzalpha associate and whether this interaction can modulate cyclic
nucleotide levels by activating the phosphodiesterase complex. The
proposed studies will quite possibly result in the first
characterization the interaction of Gzalpha with a specific effector
molecule, namely phosphodiesterase gamma.
我们对细胞如何传播的理解已经取得了很大进展
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANDREW B. NIXON其他文献
Circulating Angiokines Are Associated With Reverse Remodeling and Outcomes in Chronic Heart Failure
循环血管生成素与慢性心力衰竭的逆向重构和预后相关
- DOI:
10.1016/j.cardfail.2022.12.011 - 发表时间:
2023-06-01 - 期刊:
- 影响因子:8.200
- 作者:
JOSEPHINE Harrington;ANDREW B. NIXON;MELISSA A. DAUBERT;ERIC YOW;JAMES JANUZZI;MONA FIUZAT;DAVID J. WHELLAN;CHRISTOPHER M. O'CONNOR;JUSTIN EZEKOWITZ;ILEANA L. PIÑA;KIRKWOOD F. ADAMS;G. MICHAEL FELKER;RAVI KARRA - 通讯作者:
RAVI KARRA
ANDREW B. NIXON的其他文献
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{{ truncateString('ANDREW B. NIXON', 18)}}的其他基金
The Duke Senescent Cell Evaluations in Normal Tissues (SCENT) Mapping Center
杜克大学正常组织衰老细胞评估 (SCENT) 绘图中心
- 批准号:
10492746 - 财政年份:2021
- 资助金额:
$ 3.67万 - 项目类别:
Bridging SenNet and HuBMAP through spatial omics of the human intestine
通过人体肠道的空间组学桥接 SenNet 和 HuBMAP
- 批准号:
10895625 - 财政年份:2021
- 资助金额:
$ 3.67万 - 项目类别:
Angiogenic biomarker discovery to direct bevacizumab therapy in cervical cancer - Blood-based Angiome Profiling: An ancillary analysis of GOG-0240
血管生成生物标志物的发现可指导宫颈癌贝伐单抗治疗 - 基于血液的血管瘤分析:GOG-0240 的辅助分析
- 批准号:
10112674 - 财政年份:2021
- 资助金额:
$ 3.67万 - 项目类别:
Angiogenic biomarker discovery to direct bevacizumab therapy in cervical cancer - Blood-based Angiome Profiling: An ancillary analysis of GOG-0240
血管生成生物标志物的发现可指导宫颈癌贝伐单抗治疗 - 基于血液的血管瘤分析:GOG-0240 的辅助分析
- 批准号:
10322184 - 财政年份:2021
- 资助金额:
$ 3.67万 - 项目类别:
RGULATION OF CYCLIC GMP PHOSPHODIESTERASE BY GZ
广州市对环GMP磷酸二酯酶的规定
- 批准号:
6178844 - 财政年份:2000
- 资助金额:
$ 3.67万 - 项目类别:
RGULATION OF CYCLIC GMP PHOSPHODIESTERASE BY GZ
广州市对环GMP磷酸二酯酶的规定
- 批准号:
2709069 - 财政年份:1999
- 资助金额:
$ 3.67万 - 项目类别:
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