Biological Analysis Core
生物分析核心
基本信息
- 批准号:10689785
- 负责人:
- 金额:$ 74.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-30 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:18 year oldAdultAgingAtherosclerosisAtlasesBiologicalBiological AssayBiological MarkersBloodBronchoalveolar LavageCell AgingCell NucleusCellsCerebrospinal FluidChildhoodChromatinChronic DiseaseClinical ResearchCollaborationsColonComplexDataData AnalysesDevelopmentDimensionsElderlyElementsEnsureEnvironmentEnzyme-Linked Immunosorbent AssayEpigenetic ProcessEvaluationFlow CytometryFoundationsGenerationsGenus MenthaGoalsGrowthHeartHeterogeneityHumanHypoxiaImmuneIn VitroInfantInterventionLungMalignant NeoplasmsMapsMeasurementMeasuresMethodsMicrofluidicsModelingMolecularMorphologyMuscleNerve DegenerationNormal tissue morphologyOrganOrganoidsPhenotypePreventionProteinsPulmonary FibrosisRecording of previous eventsResearchResearch PersonnelResolutionResourcesSalivaSamplingScienceScientistSkinSpatial DistributionStainsStandardizationStructure of parenchyma of lungSystemTP53 geneTechnologyTissue BanksTissue PreservationTissue atlasTissuesTransposaseUrineWorkage groupbeta-Galactosidasebiomarker identificationblood fractionationcell injurycell typechromatin immunoprecipitationefficacy testingexperiencefetalfunctional genomicsgenotoxicityhigh dimensionalityhistone modificationmitochondrial dysfunctionmultimodalitymultiple omicsnovelnovel therapeuticsnutrient deprivationresponsesenescencestressortelomeretissue mappingtooltranscriptome sequencingtranscriptomicswound healingyoung adult
项目摘要
ABSTRACT – Biological Analysis Core
Cellular senescence is a prolonged and generally irreversible growth arrest observed in normal tissue
development. While senescence is vital for tissue remodeling, for prevention of malignancy in damaged cells,
and in wound healing, the aberrant accumulation of senescence cells is associated with multiple chronic
diseases of aging such as atherosclerosis, pulmonary fibrosis, neurodegeneration and others. Senescence is
seen as a response to various stressors including telomere erosion, genotoxicity, nutrient deprivation, hypoxia,
and mitochondrial dysfunction. The Biological Analysis Core, in partnership with the Biospecimen Core, will be
a critical resource for the SenNet proposal by integrating and delivering state-of-the-art technology to investigate
senescence at the molecular, single-cell, and whole tissue level. The core is led by a team of highly accomplished
research scientists who have successfully utilized these specific platforms in conjunction with previous and/or
current clinical studies. Together with the Data Analysis Core, the Biological Analysis Core will generate
multimodal atlases that characterize the heterogeneity and spatial distribution of senescent cells at single cell
resolution in various tissues including lung, heart, colon, muscle, and skin and across different stages of
development consisting of fetal/infant, pediatric (<18 years old), young adults (<35), middle adults (<55), and
older adults (>55). To support the consortium and provide the requisite set of senescence maps across different
tissues, Biological Analysis Core will utilize a comprehensive repertoire of highly standardized and/or formally
validated assay platforms. With the initial focus on lung tissue, we will systematically profile heart, muscle, skin
and colon tissues to provide rich tissue maps of senescence across all above-defined age groups. The Biological
Analysis Core has the following Specific Aims: 1) to provide high resolution state-of-the-art molecular, cellular,
and tissue-level characterization of biospecimens for the purpose of identifying robust biomarkers of senescence
and constructing detailed tissue maps, 2) to collect and analyze matching biofluids including blood, cerebrospinal
fluid, saliva, and urine, providing a broader interconnection between the senescence maps across multiple
tissues and at varying developmental stages, and 3) to develop human-derived microfluidic-based droplet
organoids from various tissues to model unique systems amenable to perturbations that test the efficacy of novel
drugs for senescence intervention. All of these samples, derivatives, and data will be available to the entire
Tissue Mapping Center consortium and our team will work to integrate and optimize all parts of the data
generation pipeline, from tissue collection and preservation to data generation, integration, analysis, and
interpretation.
摘要:生物分析核心
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANDREW B. NIXON其他文献
Circulating Angiokines Are Associated With Reverse Remodeling and Outcomes in Chronic Heart Failure
循环血管生成素与慢性心力衰竭的逆向重构和预后相关
- DOI:
10.1016/j.cardfail.2022.12.011 - 发表时间:
2023-06-01 - 期刊:
- 影响因子:8.200
- 作者:
JOSEPHINE Harrington;ANDREW B. NIXON;MELISSA A. DAUBERT;ERIC YOW;JAMES JANUZZI;MONA FIUZAT;DAVID J. WHELLAN;CHRISTOPHER M. O'CONNOR;JUSTIN EZEKOWITZ;ILEANA L. PIÑA;KIRKWOOD F. ADAMS;G. MICHAEL FELKER;RAVI KARRA - 通讯作者:
RAVI KARRA
ANDREW B. NIXON的其他文献
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{{ truncateString('ANDREW B. NIXON', 18)}}的其他基金
The Duke Senescent Cell Evaluations in Normal Tissues (SCENT) Mapping Center
杜克大学正常组织衰老细胞评估 (SCENT) 绘图中心
- 批准号:
10492746 - 财政年份:2021
- 资助金额:
$ 74.67万 - 项目类别:
Bridging SenNet and HuBMAP through spatial omics of the human intestine
通过人体肠道的空间组学桥接 SenNet 和 HuBMAP
- 批准号:
10895625 - 财政年份:2021
- 资助金额:
$ 74.67万 - 项目类别:
Angiogenic biomarker discovery to direct bevacizumab therapy in cervical cancer - Blood-based Angiome Profiling: An ancillary analysis of GOG-0240
血管生成生物标志物的发现可指导宫颈癌贝伐单抗治疗 - 基于血液的血管瘤分析:GOG-0240 的辅助分析
- 批准号:
10112674 - 财政年份:2021
- 资助金额:
$ 74.67万 - 项目类别:
Angiogenic biomarker discovery to direct bevacizumab therapy in cervical cancer - Blood-based Angiome Profiling: An ancillary analysis of GOG-0240
血管生成生物标志物的发现可指导宫颈癌贝伐单抗治疗 - 基于血液的血管瘤分析:GOG-0240 的辅助分析
- 批准号:
10322184 - 财政年份:2021
- 资助金额:
$ 74.67万 - 项目类别:
RGULATION OF CYCLIC GMP PHOSPHODIESTERASE BY GZ
广州市对环GMP磷酸二酯酶的规定
- 批准号:
6178844 - 财政年份:2000
- 资助金额:
$ 74.67万 - 项目类别:
RGULATION OF CYCLIC GMP PHOSPHODIESTERASE BY GZ
广州市对环GMP磷酸二酯酶的规定
- 批准号:
2709069 - 财政年份:1999
- 资助金额:
$ 74.67万 - 项目类别:
RGULATION OF CYCLIC GMP PHOSPHODIESTERASE BY GZ
广州市对环GMP磷酸二酯酶的规定
- 批准号:
6018420 - 财政年份:1999
- 资助金额:
$ 74.67万 - 项目类别:
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