HIGH-POWER INTERSTITIAL ULTRASOUND LIVER TUMOR ABLATION

高功率间质超声肝脏肿瘤消融术

• 批准号: 6322435
• 负责人: EVERETTE C. BURDETTE
• 金额: $ 10万
• 依托单位: BURDETTE MEDICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-11 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6322435
• 关键词: biomedical equipment development; computer system design /evaluation; interstitial; liver neoplasms; neoplasm /cancer thermotherapy; swine; ultrasound therapy

The objective of this proposed effort is to develop and evaluate high- powered interstitial ultrasound applicator technology and support systems specifically for thermal ablation of liver tumors. Recent investigations with interstitial ultrasound applicators in prostate and moderately perfused tissues have demonstrated extremely controllable and penetrating heating patterns which can be shaped and dynamically altered, providing an ideal mechanism for conformable thermal surgery. In order to extend this technology to liver ablation, the following Phase I studies are proposed: (1) modify existing applicator technology for high- power devices required for liver tumor ablation; (2) perform theoretical investigations of new power application schemes and design parameters specific to ablating liver tumors; (3) develop and integrate system hardware and software for a controlling system prototype; and (4) perform in vivo liver experiments to evaluate applicators and support systems. The feasibility of controlled/conformal treatment of transversely and longitudinally larger tumor volumes in shorter time frames and with greater control will be assessed as compared to existing RF, Laser, and Microwave technology. The results and experience obtained from these studies will be applied to the conceptual development of clinical approaches and procedures in the treatment of liver tumors, with proposed implementation in the succeeding Phase II application. PROPOSED COMMERCIAL APPLICATIONS: Minimally-invasive thermal ablation of liver tumors is a clinically viable technique which provides a less morbid alternative to surgery, and can be applied in patients whose disease is not surgically resectable or are a poor risk for open surgery. Current technology is limited to treating spherically shaped tumors <3cm effectively. High-power interstitial ultrasound technology has significant potential to treat larger tumors of complex shapes in controllable and faster manner, permitting more effective treatment for larger number of cases.

这项工作的目标是开发和评估专门用于肝脏肿瘤热消融的高功率间质超声施用器技术和支持系统。最近对间质超声探头在前列腺和中等灌注组织中的研究表明，加热模式极其可控和具有穿透力，可以成形和动态改变，为适形热手术提供了理想的机制。为了将该技术推广到肝脏消融领域，拟开展以下一期研究：（1）修改现有肝脏肿瘤消融所需大功率装置的治疗器技术； （2）针对消融肝脏肿瘤的新功率应用方案和设计参数进行理论研究； (3) 开发并集成控制系统原型的系统硬件和软件； (4) 进行体内肝脏实验以评估施用器和支持系统。与现有的射频、激光和微波技术相比，将评估在更短的时间内和更好的控制下对横向和纵向较大肿瘤体积进行受控/适形治疗的可行性。从这些研究中获得的结果和经验将应用于肝脏肿瘤治疗临床方法和程序的概念开发，并建议在后续的二期应用中实施。拟议的商业应用：肝脏肿瘤的微创热消融是一种临床上可行的技术，它提供了一种比手术更少的发病率替代方案，并且可以应用于疾病无法通过手术切除或开放手术风险较低的患者。目前的技术仅限于有效治疗<3cm的球形肿瘤。高功率间质超声技术具有以可控且更快的方式治疗形状复杂的较大肿瘤的巨大潜力，可以对大量病例进行更有效的治疗。