TAS::75 0872::TAS 2010 SBIR PHASE I TOPIC 55

TAS::75 0872::TAS 2010 SBIR 第一阶段主题 55

• 批准号: 8165745
• 负责人: EVERETTE C. BURDETTE
• 金额: $ 18.84万
• 依托单位: ACOUSTIC MEDSYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2011-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8165745
• 关键词: Ablation; Acoustics; Award; Budgets; Businesses; Cardiac ablation; Catheters; Contracts; Development; Devices; Disease; Economically Deprived Population; Environment; Extramural Activities; Focused Ultrasound Therapy; Fostering; Funding; Government; Laboratories; Magnetic Resonance Imaging; Pathology; Performance; Phase; Positioning Attribute; Private Sector; Research; Small Business Innovation Research Grant; Statutes and Laws; Technology; Testing; Therapeutic; Tissues; United States Dept. of Health and Human Services; United States Public Health Service; Woman; base; commercialization; heart rhythm; improved; novel strategies; operation; programs; research and development; tumor

The Small Business Research and Development Enhancement Act of 1992 requires the agencies of the Public Health Service, Department of Health and Human Services and certain other federal agencies to reserve 2.5% of their current fiscal year extramural budgets for research or research and development for an SBIR program. The legislation is intended to: expand and improve the SBIR program; emphasize increased private sector commercialization of technology developed through federal SBIR R&D; increase small business participation in Federal R&D, and foster and encourage participation of socially and economically disadvantaged small business concerns and women owned small business concerns in the SBIR program. The Small Business Innovation Research program consists of three phases. The objective of Phase I is to determine the scientific, technical, and commercial merit and feasibility of the proposed research or R&D efforts and the quality of performance of the small business concern, prior to providing further Federal support in Phase II. Phase II awards continue the research or R&D efforts initiated in Phase I. Funding shall be based on the results of Phase I and the scientific and technical merit and commercial potential of the Phase II proposal. The Phase III objective is for the small business concern to pursue with non-federal funds the commercialization of the results of the research or R&D funded in Phases I and II. The purpose of this Phase I contract is to support Acoustic MedSystems, Inc in the development of a catheter capable of targeting and delivering high intensity focused ultrasound (HIFU) ablative energy under magnetic resonance imaging (MRI) guidance. This would be attractive because MRI can identify pathology in target tissue, guide positioning of therapeutic devices, and guide thermal alterations during delivery of energy. This MRI-guided HIFU technology would enable novel approaches to therapy for cardiac rhythm disorders as well as ablation therapy for endocavitary tumors. The sponsoring government laboratory intends to use this MRI HIFU ablation catheter for the treatment of cardiac rhythm disorders, and offers to assist the awardee in packaging and testing their HIFU technology for operation in an MRI environment.

1992年的《小企业研究与发展促进法》要求公共卫生服务、卫生与公众服务部和某些其他联邦机构将其当前财政年度校外预算的2.5%用于SBIR计划的研究或研究与发展。该立法的目的是：扩大和改进SBIR计划;强调增加私营部门通过联邦SBIR研发开发的技术的商业化;增加小企业对联邦研发的参与，并促进和鼓励社会和经济弱势的小企业和女性拥有的小企业参与SBIR计划。 小企业创新研究计划包括三个阶段。第一阶段的目标是在第二阶段提供进一步的联邦支持之前，确定拟议研究或研发工作的科学、技术和商业价值和可行性，以及小企业的绩效质量。第二阶段的奖励继续在第一阶段开始的研究或研发工作。资助应基于第一阶段的结果以及第二阶段提案的科学技术价值和商业潜力。第三阶段的目标是让小企业利用非联邦基金将第一阶段和第二阶段资助的研究或研发成果商业化。 该第一阶段合同的目的是支持Acoustic MedSystems，Inc开发一种能够在磁共振成像（MRI）引导下靶向和输送高强度聚焦超声（HIFU）消融能量的导管。这将是有吸引力的，因为MRI可以识别目标组织中的病理，引导治疗设备的定位，并在能量输送期间引导热变化。这种MRI引导的HIFU技术将使新的方法来治疗心律失常以及消融治疗腔内肿瘤。赞助的政府实验室打算使用该MRI HIFU消融导管治疗心律失常，并提供协助获奖者包装和测试其HIFU技术在MRI环境中的操作。