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Quantitative C-arm Fluoroscopy - Prostate Brachytherapy

定量 C 形臂透视 - 前列腺近距离放射治疗

基本信息

批准号：
7492892
负责人：
EVERETTE C. BURDETTE
金额：
$ 38.97万
依托单位：
BURDETTE MEDICAL SYSTEMS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-07-01 至 2009-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7492892
关键词：
Algorithms Anatomy Brachytherapy Calibration Caring Clinical Data Development Dose Environment Evaluation Fluoroscopy Goals Health Hospitals Human Image Imagery Implant Individual Intervention Malignant neoplasm of prostate Manuals Methods Modeling Morphologic artifacts Operating Rooms Patients Performance Phase Positioning Attribute Prostate Prostate Cancer therapy Quality Control Radiation Research Research Ethics Committees Research Project Grants Safety Seed Implantation Small Business Funding Mechanisms Small Business Innovation Research Grant Standards of Weights and Measures System Testing Time Tissues Today Transrectal Ultrasound Ultrasonography United States Food and Drug Administration Upper arm Validation concept coping design dosimetry mathematical algorithm pre-clinical reconstruction research clinical testing soft tissue success

项目摘要

Prostate cancer continues to be a significant health problem, both domestically and worldwide. Numerous studies have demonstrated the efficacy and safety of transperineal prostate brachytherapy in the therapy of prostate cancer. The success of brachytherapychiefly depends on our ability to intra-operatively tailor the radiation dose to the patient's individual anatomy. Thus the objective of this research is to design, develop, and clinically test a method for intra-operative localization of the implanted seeds in relation to the prostate, to allow for intra-operative dosimetric optimization and exit dosimetry.Brachytherapy is predominantly performed with transrectal ultrasound guidance, which provides adequate real-time visualization of soft tissue anatomy, but does not showthe implanted seeds. To overcomethis problem, we propose registration of ultrasound to intra-operative C-arm fluoroscopy, wherethe implanted seeds will be reconstructed from fluoroscopy and superimposed on ultrasound. In particular, we will: (1) Design a system and workflow that is consistent with contemporary practice of prostate brachytherapy. (2) Developoptimized mathematical algorithms for reconstruction of seed implants from C-arm fluoroscopy images, spatial registration of fluoroscopy and ultrasound imaging. (3) Integrate the algorithms with an existing commercialprostate brachytherapy systemand implant optimization methods. (4) Conduct Clinical SystemPerformance Evaluation Trial on human patients. We have establishedthe technical feasibility of this approachin a Phase-1 SBIR research grant. We are requesting Phase-2 support to develop a clinical-grade system and evaluate its technical performanceon human patients. The resulting system will withstand the scrutiny of subsequent FDA approvaland enter wide-spread clinical use via commercial dispersion.

前列腺癌仍然是一个重大的健康问题，在国内和世界范围内。众多