MICROWAVE PHASED ARRAY FOR HYPERTHERMIA CANCER THERAPY

本课题的目标是研制一台微波相控阵样机。 用于局部肿瘤热疗的敷贴器。治疗性 聚焦治疗可提高电离放射治疗的疗效 对肿瘤进行加热。利用微波发电 局部热疗已成功地应用于动物和 临床研究。然而，目前微波辐射器的设计中存在热 只有表浅的肿瘤，必须机械移动才能改变 肿瘤及周围正常组织中的能量分布。这个 拟议的第一阶段研究的具体目标是开发新的 利用微波产生局部肿瘤热疗的技术。 初步研究已经产生了一种新的微波相控器设计 阵列式热疗喷头。拟议的第一阶段研究将允许 将这一现有设计发展成工作的微波原型 热疗应用系统。该喷头系统将由一个 微波相控阵施加器、微波功率放大器和 分配网络，以及用于施加器的计算机控制系统。 这种新的微波相控阵应用系统将具有 在组织中比目前更有效地聚焦微波能量 可用的临床设备和焦点位置将是 电子扫描而不是机械扫描，以便产生 肿瘤温度分布均匀，周围无过热 正常组织。第一阶段研究的结果将提供一个基础 用于联合放射和热疗治疗的人体临床试验。

The goal of this project is to develop a prototype microwave phased array applicator for local tumor hyperthermia therapy. The therapeutic effectiveness of ionizing radiation therapy can be improved by the focused application of heat to the tumor. The use of microwaves for the generation of local hyperthermia has been successfully applied in both animal and clinical studies. However, current designs for microwave applicators heat only superficial tumors and must be mechanically moved in order to change the power distribution in the tumor and surrounding normal tissues. The specific aims of the proposed Phase I study are designed to develop new techniques for producing local tumor hyperthermia using microwaves. Preliminary studies have resulted in a new design for a microwave phased array hyperthermia applicator. The proposed Phase I studies will allow development of this existing design into a working prototype microwave hyperthermia applicator system. This applicator system will consist of a microwave phased array applicator, a microwave power amplifier and distribution network, and a computer control system for the applicator. This new microwave phased array applicator system will have the capability of focusing microwave energy more effectively in tissue than presently available clinical devices and the location of the focus will be electronically rather than mechanically scanned in order to produce a uniform tumor temperature distribution without overheating surrounding normal tissues. The results of the Phase I studies will provide a basis for human clinical trials of combined radiation and hyperthermia therapy.