C-arm Fluoroscopy for Prostate Brachytherapy

用于前列腺近距离放射治疗的 C 形臂透视

• 批准号: 6585752
• 负责人: EVERETTE C. BURDETTE
• 金额: $ 16.63万
• 依托单位: BURDETTE MEDICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6585752
• 关键词: X ray; bioimaging /biomedical imaging; biomedical automation; computer assisted patient care; computer program /software; fluoroscopy; medical implant science; neoplasm /cancer radionuclide therapy; phantom model; prostate neoplasms; radiation dosage; radionuclide imaging /scanning; radionuclide implant; technology /technique development; time resolved data

DESCRIPTION (provided by applicant): A technique is proposed for the development of an intraoperative, 3-dimensional registration of C-arm fluoroscopic images with spatially-registered ultrasound visualization and implant guidance of radioactive implants and on-line implant assessment during the procedure for treatment of prostate cancer. With present techniques using transrectal ultrasound guidance for brachytherapy, intra-operative localization of implanted seeds with respect to soft tissue anatomy is still an unsolved problem. Ultrasound (US) images provide satisfactory differentiation of relevant soft issue, but implanted brachytherapy seeds cannot be clearly identified in the US images. Currently sixty percent of the practitioners use intra-operative C-arm fluoroscopy as a qualitative check of the implants. While seeds can be accurately localized in X-ray, projected transluminal images do not reveal soft tissue anatomy. Hence, there is a standing clinical need to couple relevant information from C-arm with the US-guided delivery system, in a safe, robust, and cost-efficient manner. The goal of the proposed work is to implement intra-operative dosimetric quality assurance in transrectal US-guided prostate brachytherapy with the use of C-arm X-ray fluoroscopy. The specific objective of this program is to incorporate spatial location of implanted seeds determined from C-arm X-ray fluoroscopy images with soft tissue anatomy determined from ultrasound images. This will enable the actual dose distribution to be compared to the dose pre-plan and assessed while the implant process is underway. Thus, immediate therapeutic intervention would be possible to correct for any "cold" regions or minimize "hot" regions near critical structures and exactly "match" the optimal source placement within the treatment volume. The outcome of this research could be of immediate benefit in the treatment of prostate cancer. It would provide the ability to visualize in real time the placement of implants, providing implants which reflect optimal dosimetry. A large group of patients with early-stage disease are candidates.

描述（由申请人提供）：提出了一种技术，用于开发C形臂荧光透视图像的术中三维配准，并在前列腺癌治疗过程中进行空间配准超声可视化和放射性植入物的植入引导以及在线植入物评估。对于使用经直肠超声引导进行近距离放射治疗的现有技术，植入的粒子相对于软组织解剖结构的术中定位仍然是一个未解决的问题。超声（US）图像可对相关软组织进行令人满意的区分，但植入的近距离放射治疗粒子无法在US图像中清晰识别。目前，60%的从业者使用术中C形臂透视作为植入物的定性检查。虽然放射性粒子可以在X射线中准确定位，但投影的经腔图像不能显示软组织解剖结构。因此，临床上一直需要以安全、稳健和具有成本效益的方式将来自C形臂的相关信息与超声引导输送系统相结合。拟议工作的目标是使用C形臂X射线透视在经直肠US引导的前列腺近距离放射治疗中实施术中剂量测定质量保证。该程序的具体目标是将根据C形臂X射线透视图像确定的植入粒子的空间位置与根据超声图像确定的软组织解剖结构相结合。这将使实际剂量分布能够与剂量预先计划进行比较，并在植入过程进行时进行评估。因此，立即的治疗干预将可能校正任何“冷”区域或最小化关键结构附近的“热”区域，并且精确地“匹配”治疗体积内的最佳源放置。 这项研究的结果可能对前列腺癌的治疗有直接的好处。它将提供在真实的时间内可视化植入物放置的能力，从而提供反映最佳剂量测定的植入物。一大批患有早期疾病的患者是候选人。

项目成果

C-arm calibration--is it really necessary?

C型臂校准——真的有必要吗？

• DOI: 10.1007/11566465_79
• 发表时间: 2005
• 期刊: Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
• 作者: Jain,Ameet;Kon,Ryan;Zhou,Yu;Fichtinger,Gabor
• 通讯作者: Fichtinger,Gabor

Intra-operative 3D guidance and edema detection in prostate brachytherapy using a non-isocentric C-arm.

使用非以上为中心的C型臂在前列腺放射治疗中术中3D指导和水肿检测。

• DOI: 10.1016/j.media.2010.07.011
• 发表时间: 2012-04
• 期刊: Medical image analysis
• 影响因子: 10.9
• 作者: Jain A;Deguet A;Iordachita I;Chintalapani G;Vikal S;Blevins J;Le Y;Armour E;Burdette C;Song D;Fichtinger G
• 通讯作者: Fichtinger G