SENSITIVE IMMUNOASSAY FOR HIV-1 P24 IN MOTHER'S MILK

描述：（改编自提案摘要）BIOTRACES Inc.具有 开发了一种新型的同位素多光子探测系统， 比标准检测系统灵敏一千倍所述MPD 增强免疫分析是一种适用于研究和临床的新技术， 优化的设施，用于生物分子的最高灵敏度定量。 这项研究的目的是利用这项新技术， 建立一种快速、可靠、定量的HIV-1 p24抗原免疫检测方法 存在于母亲的乳汁中。与当前“最先进”的ELISA相比， MPD增强的免疫测定允许约1,000倍的更高灵敏度。 在每ml血清中约10至50个病毒粒子的水平上的定量是 预期更具体地说，这种用于p24抗原的新测定法将用于 艾滋病毒1型母婴传播的研究。 拟议商业应用：不可用

DESCRIPTION: (Adapted from the proposal's abstract) BIOTRACES Inc. has developed a novel Multiple Photon DetectionTM (MPDTM) system for isotopes which is a thousand times more sensitive than standard detection systems. The MPD enhanced immunoassay is a new technique appropriate for research and clinical facilities optimized for the highest sensitivity quantitation of biomolecules. The objective of the proposed research is to utilize this new technology to develop a fast, reliable and quantitative immunoassay for HIV-1 p24 antigen present in mother's milk. When compared with current "state of the art" ELISAs the MPD enhanced immunoassay permits about a 1,000 fold greater sensitivity. Quantitation on the level of about ten to fifty virions per ml of serum is expected. More specifically, this new assay for p24 antigen will be used in studies of the transmission of HIV-1 from mother to child. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE