Supersensitive Detection of Viral BioWarfare Agents

病毒生物战剂的超灵敏检测

• 批准号: 6643271
• 负责人: Andrzej K Drukier
• 金额: $ 9.76万
• 依托单位: BIOTRACES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2003-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6643271
• 关键词: biohazard detection; biomedical equipment development; bioterrorism /chemical warfare; electromagnetic radiation; immunologic assay /test; microarray technology; nucleic acid quantitation /detection; protein quantitation /detection; virus characteristic

DESCRIPTION (provided by applicant): The ability to detect biological agents across a large number of diverse locations, all of which might be targets for terrorists, is currently limited by the restricted sensitivity and non-portability of available detection systems. BioTraces, Inc. has developed a new family of MPD systems that overcome these existing limitations. MPD has several advantages over existing assay methods: better than 1,000-fold improvement in sensitivity, enabling measurement of previously undetectable amounts of target substances; concurrent measurement of multiple samples, leading to higher throughput, and the ability to perform simultaneous assays for multiple targets in a single sample using portable, light weight instruments. The proposed applications of MPD for the detection of biological warfare agents can be divided into two synergistic sub-projects: * use of a panel of MPD enhanced immunoassays for detection of viral BW agents. * development of a universal biological warfare agent detector using supersensitive P-chips/MPD. Recent events in the US have shown the vulnerability of domestic institutions to terrorist activities. Over the next few years a significant market for means of detecting and preventing terrorist attacks will develop. Because of the superior sensitivity of MPD techniques, BioTraces is in a position to capture a significant share of the detection aspect of this emerging market.

说明（由申请方提供）：目前，由于现有探测系统的灵敏度有限且不便于携带，因此在许多不同地点探测生物制剂的能力受到限制，而这些地点都可能成为恐怖分子的目标。BioTraces公司已经开发了一种新的MPD系统系列，克服了这些现有的限制。与现有的检测方法相比，MPD具有几个优点：灵敏度提高了1,000倍以上，能够测量以前无法检测到的目标物质;同时测量多个样品，从而提高了通量，并能够使用便携式轻质仪器对单个样品中的多个目标进行同时检测。 将MPD用于检测生物战剂的拟议应用可分为两个协同增效的子项目：* 使用一组MPD增强免疫测定法检测病毒性生物战剂。 * 使用超灵敏P芯片/MPD开发通用生物战剂探测器。 美国最近发生的事件表明，国内机构容易受到恐怖主义活动的影响。在今后几年里，将发展一个探测和防止恐怖主义袭击手段的重要市场。由于MPD技术的上级灵敏度，BioTraces能够在这一新兴市场的检测方面占据重要份额。