Supersensitive Detection of Viral BioWarfare Agents

描述（由申请人提供）：在大量不同地点检测生物制剂的能力，所有这些地点都可能成为恐怖分子的目标，目前受到现有检测系统的有限灵敏度和不可移植性的限制。BioTraces公司开发了一系列新的MPD系统，克服了这些现有的限制。与现有的分析方法相比，MPD有几个优点：灵敏度提高了1000倍以上，可以测量以前无法检测到的目标物质；同时测量多个样品，从而提高吞吐量，并且能够使用便携式轻质仪器对单个样品中的多个目标进行同时分析。MPD用于检测生物战制剂的拟议应用可分为两个协同子项目：*使用一组MPD增强免疫测定来检测病毒性生物武器制剂。*使用超灵敏p -芯片/MPD开发通用生物战剂探测器。美国最近发生的事件表明，国内机构在恐怖主义活动面前不堪一击。在接下来的几年里，侦测和预防恐怖袭击手段的重要市场将会发展。由于MPD技术的卓越灵敏度，BioTraces在这个新兴市场的检测方面占据了重要的份额。

DESCRIPTION (provided by applicant): The ability to detect biological agents across a large number of diverse locations, all of which might be targets for terrorists, is currently limited by the restricted sensitivity and non-portability of available detection systems. BioTraces, Inc. has developed a new family of MPD systems that overcome these existing limitations. MPD has several advantages over existing assay methods: better than 1,000-fold improvement in sensitivity, enabling measurement of previously undetectable amounts of target substances; concurrent measurement of multiple samples, leading to higher throughput, and the ability to perform simultaneous assays for multiple targets in a single sample using portable, light weight instruments. The proposed applications of MPD for the detection of biological warfare agents can be divided into two synergistic sub-projects: * use of a panel of MPD enhanced immunoassays for detection of viral BW agents. * development of a universal biological warfare agent detector using supersensitive P-chips/MPD. Recent events in the US have shown the vulnerability of domestic institutions to terrorist activities. Over the next few years a significant market for means of detecting and preventing terrorist attacks will develop. Because of the superior sensitivity of MPD techniques, BioTraces is in a position to capture a significant share of the detection aspect of this emerging market.