BIOCIDAL POLYMERS FOR DENTAL WATER CONTAMINATION CONTROL

用于控制牙科用水污染的杀菌聚合物

• 批准号: 2713304
• 负责人: JEFFREY F WILLIAMS
• 金额: $ 9.95万
• 依托单位: HALOSOURCE CORPORATION
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 1999-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2713304
• 关键词: antiinfective agents; clinical biomedical equipment; communicable disease control; dental research; dentistry; electron microscopy; polymers; surface coating; water microbiology; water quality; water supply; water treatment

In this research proposal an entirely novel chemical technology is applied to a problem of national importance to the healthcare industry, arising from "device related infections" during patient care (1,2). Microbial contamination of in-dwelling devices is commonplace and is not satisfactorily resolved by currently available approaches (silver impregnated catheters, or silver/antimicrobial combinations (3,4)). Recent advances in N- Halamine polymer chemistry permit the creation of "contact biocidal" surfaces expressing rapid, potent efficacy against bacterial and viral pathogens in fluid streams (5,6). New developments provide for coatings to be laid down on substrates commonly used in medical devices; these coatings show about 100% control of Pseudomonas biofilm formation in 72 hour experiments (7). In the proposed studies, quantitative microbiological evaluations of adherent organisms, fluorescence microscopy of live/dead differentiation, and scanning and transmission election microscopy will be used to characterize a range of novel polymeric compounds (7), over time and in the presence of a variety of organic bioburdens. Results will be used in selection of polymeric coating procedures to be evaluated as candidates for further development as components of "infection resistant" devices (such as catheters, shunts, urine and colostomy bags) with far reaching commercial and health care implications nationally and internationally. PROPOSED COMMERCIAL APPLICATION: Commercial applications include cartridges to be included in the dental unit waterlines so as to provide an antimicrobial, decontaminating component in the pathway of water to the patient. Also possible is the development of tubing or devices that could be periodically re-charged with antibacterial activity by exposure to bleach (hypochlorite) as a means of maintaining control over microbial contamination of dental unit water. Application to the control of air quality is also possible, depending on the configuration of the decontamination pathway devised to incorporate the antimicrobial polymers.

在这项研究提案中，一种全新的化学技术被应用于对医疗保健行业具有国家重要性的问题，该问题是由患者护理过程中的“器械相关感染”引起的（1，2）。留置器械的微生物污染是常见的，目前可用的方法（银浸渍导管或银/抗菌剂组合（3，4））不能令人满意地解决。N-卤胺聚合物化学的最新进展允许产生“接触杀生物”表面，其对流体流中的细菌和病毒病原体表现出快速、有效的功效（5，6）。新的发展提供了涂覆在医疗器械中常用的基材上的涂层;这些涂层在72小时实验中显示出对假单胞菌生物膜形成的约100%控制（7）。 在拟议的研究中，粘附微生物的定量微生物评价、活/死区分的荧光显微镜检查以及扫描和透射电子显微镜检查将用于表征一系列新型聚合物化合物（7），随着时间的推移，并在各种有机bidens的存在下。结果将用于选择聚合物涂层程序，以作为进一步开发的“抗感染”器械（如导管、分流器、尿袋和结肠造口术袋）组件的候选程序进行评价，这些组件在国内和国际上具有深远的商业和医疗保健影响。拟定商业应用：商业应用包括将被包括在牙科综合治疗台水管线中的药筒，以便在通向患者的水的路径中提供抗微生物、净化组分。还可能开发通过暴露于漂白剂（次氯酸盐）定期重新充满抗菌活性的管道或装置，作为保持对牙科综合治疗台水的微生物污染的控制的手段。也可以应用于控制空气质量，这取决于设计用于结合抗微生物聚合物的净化路径的配置。