COLLABORATIVE RESEARCH ON PARASITIC DISEASES IN SUDAN

这是一个合作项目， 州立大学医学院和卫生部的教职员工 卫生和医学系，喀土穆大学，苏丹民主共和国 苏丹共和国. 它着重于三种主要热带疾病的基本方面 对健康、生产力、进步和发展造成重大制约的实体 苏丹人民的潜力。 1980年9月至8月 1981年），我们建议在我们目前努力奠定的基础上， 在苏丹建立、改造和装备实验室和外地基地， 制定来自世界各地的科学参与者之间的合作协议， 所有参与的机构，并划定合理的方案， 调查，适合优先事项，环境和眼前的机会 在苏丹。 在血吸虫病方面，我们打算巩固我们的初步研究， 关于苏丹使用的治疗方案及其在医疗中的地位， 保健和预防性医疗战略，制定详细的 临床/药理学研究方案：这将适用于 目前常规管理的代理商和其他我们希望 在评估其是否适合试验目的时，可以访问。 在疟疾中， 我们将开始收集和鉴定恶性疟原虫菌株， 测量免疫因素对药物体外测定结果的影响 灵敏度 结果将与来自 非洲、亚洲和拉丁美洲。 盘尾丝虫病在苏丹的传播将是 通过实地收集关于病媒类型、可用性和 分布情况，并与关于感染率的流行病学数据相关， 在人类中的强度。 将进行初步研究， 检测和纯化O. 肠扭转的免疫病理学工作的未来。

This is a collaborative project between biomedical researchers at the Michigan State University schools of medicine, and faculty and staff at the Ministry of Health, and Faculty of Medicine, University of Khartoum, Democratic Republic of Sudan. It focuses on fundamental aspects of three major tropical disease entities which impose major constraints on the health, productivity, progress and potential of the Sudanese people. In the coming year (September 1980-August 1981) we propose to build on the foundations laid by our current efforts in the establishment, renovation and equipping of laboratory and field bases in Sudan, the development of cooperative agreements between scientific participants from all the institutions involved, and the delineation of reasonable programs of investigation, suited to the priorities, environment and immediate opportunities in Sudan. In schistosomiasis, we intend to consolidate our preliminary studies on the spectrum of therapeutic regimens used in Sudan and their place in medical care and preventive medical strategies, by developing a detailed clinical/pharmacological investigative protocol: this will be applied both to the agents presently routinely administered and to others to which we hope to have access as their suitability for trial purposes is evaluated. In malaria, we shall begin to collect and characterize Plasmodium falciparum strains, and measure the effects of immune factors on the outcome of in vitro assays of drug sensitivity. Results will be evaluated in relation to other strains from Africa, Asia and Latin America. Onchocerciasis transmission in Sudan will be studied through field collections of data on vector type, availability and distribution and correlated with epidemiological data on infection rates and intensity in humans. Preliminary studies will be undertaken to develop immunologic reagents for the detection and purification of antigens of O. volvulus for immunopathological work in the future.