COLLABORATIVE RESEARCH ON PARASITIC DISEASES IN SUDAN

这是密歇根大学生物医学研究人员之间的合作项目。 州立大学医学院和卫生部的教职员工 卫生和医学院，喀土穆大学，民主共和国 苏丹。它集中在三种主要热带疾病的基本方面 对健康、生产力、进步造成重大制约的实体 和苏丹人民的潜力。来年(1980年9月至8月) 1981)我们建议在我们目前努力的基础上， 在苏丹建立、翻新和装备实验室和实地基地， 科学参与者之间的合作协议从 所有涉及的机构，以及合理的方案的划定 调查，与优先事项、环境和眼前机会相适应 在苏丹。在血吸虫病方面，我们打算巩固我们的初步研究 关于苏丹使用的治疗方案的范围及其在医学上的地位 护理和预防性医疗战略，通过制定详细的 临床/药理学研究方案：这将适用于 目前例行管理的代理和我们希望向其提供的其他代理 在评估其用于试验目的的适用性时具有访问权。在疟疾方面， 我们将开始收集和鉴定恶性疟原虫菌株，以及 检测免疫因素对药物体外检测结果的影响 敏感度。结果将与其他菌株进行对比评估 非洲、亚洲和拉丁美洲。盘尾丝虫病在苏丹的传播将是 通过现场收集有关病媒类型、可用性和 感染率和感染率的分布及其与流行病学数据的相关性 在人类中的强度。将进行初步研究，以制定 用于检测和提纯O。 为今后的免疫病理工作做准备。

This is a collaborative project between biomedical researchers at the Michigan State University schools of medicine, and faculty and staff at the Ministry of Health, and Faculty of Medicine, University of Khartoum, Democratic Republic of Sudan. It focuses on fundamental aspects of three major tropical disease entities which impose major constraints on the health, productivity, progress and potential of the Sudanese people. In the coming year (September 1980-August 1981) we propose to build on the foundations laid by our current efforts in the establishment, renovation and equipping of laboratory and field bases in Sudan, the development of cooperative agreements between scientific participants from all the institutions involved, and the delineation of reasonable programs of investigation, suited to the priorities, environment and immediate opportunities in Sudan. In schistosomiasis, we intend to consolidate our preliminary studies on the spectrum of therapeutic regimens used in Sudan and their place in medical care and preventive medical strategies, by developing a detailed clinical/pharmacological investigative protocol: this will be applied both to the agents presently routinely administered and to others to which we hope to have access as their suitability for trial purposes is evaluated. In malaria, we shall begin to collect and characterize Plasmodium falciparum strains, and measure the effects of immune factors on the outcome of in vitro assays of drug sensitivity. Results will be evaluated in relation to other strains from Africa, Asia and Latin America. Onchocerciasis transmission in Sudan will be studied through field collections of data on vector type, availability and distribution and correlated with epidemiological data on infection rates and intensity in humans. Preliminary studies will be undertaken to develop immunologic reagents for the detection and purification of antigens of O. volvulus for immunopathological work in the future.