BIOCIDAL POLYMERS FOR CONTROL OF DEVICE CONTAMINATION

在这项研究提案中，一项全新的化学技术是 适用于对医疗保健行业具有国家重要性的问题， 由病人护理过程中的“设备相关感染”引起(1，2)。 住宅设备的微生物污染很常见，但并不是 通过当前可用的方法(银牌)令人满意地解决 浸渍导管，或银/抗菌剂组合(3，4))。 N-卤胺聚合物化学的最新进展允许创建 “接触式杀生”表面表现出快速、有效的杀菌效果 流体中的细菌和病毒病原体(5，6)。新动向 规定在常用的衬底上铺设涂层 医疗器械；这些涂层显示出对假单胞菌的100%控制 72小时内生物膜的形成(7)。在拟议的研究中， 附着体的定量微生物学评价， 活/死分化的荧光显微镜，扫描和 透射式电子显微镜将用来表征一系列 新型聚合物(7)，随着时间的推移和在一种 各种有机生物贝类。评选结果将用于评选 聚合物涂层程序将作为进一步评估的候选程序进行评估 作为“抗感染”设备的部件(例如 导管、分流管、尿液和结肠造口袋)影响深远 对国内和国际商业和医疗保健的影响。 建议的商业应用： 新型N-卤胺聚合物可被证明在控制和 防止许多医疗器械表面的微生物污染 设备。聚合物涂层现在可以用广泛的 适用于生产触头的物理化学特性 医用导管和医用导管中常用的基材上的生物杀菌表面 其他设备，如聚亚安酯。成功地抑制了细菌 粘合和殖民可以打开商业产品的机会 它解决了设备相关感染问题，这是一个巨大的问题 对国内和国际卫生保健行业的重要意义。

In this research proposal an entirely novel chemical technology is applied to a problem of national importance to the healthcare industry, arising from "device related infections" during patient care (1,2). Microbial contamination of in-dwelling devices is commonplace and is not satisfactorily resolved by currently available approaches (silver impregnated catheters, or silver/antimicrobial combination (3,4)). Recent advances in N-Halamine polymer chemistry permit the creation of "contact biocidal" surfaces expressing rapid, potent efficacy against bacterial and viral pathogens in fluid stream (5,6). New developments provide for coatings to be laid down on substrates commonly used in medical devices; these coating show about 100% control of Pseudomonas biofilm formation in 72 hour experiments (7). In the proposed studies, quantitative micro-biological evaluations of adherent organisms, fluorescence microscopy of live/dead differentiation, and scanning and transmission electron microscopy will be used to characterize a range of novel polymeric compounds (7), over time and in the presence of a variety of organic bioburdens. Results will be used in selection of polymeric coating procedures to be evaluated as candidates for further development as components of "infection resistant" devices (such as catheters, shunts, urine and colostomy bags) with far reaching commercial and health care implications nationally and internationally. PROPOSED COMMERCIAL APPLICATION: Novel N-Halamine polymers could prove valuable in the control and prevention of microbial contamination of the surfaces of many medical devices. Polymer coatings can now be created with a wide range of physicochemical characteristics suitable for production of contact biocidal surfaces on substrates commonly used in medical catheters and other devices, such as polyurethane. Successful inhibition of bacterial adhesion and colonization could open up commercial product opportunities that address device related infections, a problem of enormous significance to the health-care industry nationally and internationally.