ANTIMICROBIAL TEXTILES FOR HEALTHCARE WORKER PROTECTION

卫生保健工作者在职业上暴露于传染性病原体， 体液和废物。个人防护服装和设备提供 防止病原体穿透到皮肤上的物理屏障 或膜（1）。然而，新的病原体和药物的出现- 耐药菌株提高了人们对无生命表面的认识， 包括衣服，作为传染性有机体的来源（2）。需要 更好的保护措施是至关重要的。纺织新进展 化学允许生产具有共价连接的N-卤胺的纺织品 抗微生物活性，可方便地再充电，并且表达快速， 对细菌和真菌病原体的有效功效（3，4）。我们提出 为了检测N-卤胺纺织品的抗病毒/抗菌能力， 模仿抗菌织物必须发挥作用的环境 以减少污染带来的感染风险。有包膜（VSV）和无包膜 包膜病毒（EMCV）和耐药细菌（VRE、MRSA） 血液和体液中的毒素都会成为目标接种物定量回收 适用于含有不同水平N-卤胺的纺织品 将决定生物体的存活。实验应该 确定将抗微生物活性纳入 织物，并证明使用 更广泛的病原体，包括艾滋病毒。这将导致现场 评估N-卤胺服装的防护效益。 拟议的商业应用： 如果N-卤胺处理的纺织品显示出对 重要类型的病毒和细菌病原体，甚至在血液和其他 体液，并最终可以显示出减少职业性 皮肤和粘膜暴露于病原体，商业 影响是多方面的。这一发现可能会导致合并这一点 新的纺织化学品用于生产防护服， 用于医护人员和其他人员（紧急情况和执法人员）的设备 可能有职业暴露风险的人员 病原体

Healthcare workers are occupationally exposed to infectious agents in body fluids and wastes. Personal protection garments and devices provide physical barriers to prevent strike-through of disease agents onto skin or membranes (1). However, the emergence of new pathogens and drug- resistant strains has heightened awareness of inanimate surfaces, including clothing, as sources of transmissible organisms (2). The need for better protective measures is paramount. Recent advances in textile chemistry permit production of textiles with covalently linked N-Halamine antimicrobial activity, conveniently rechargeable, and expressing rapid, potent efficacy against bacterial and fungal pathogens (3,4). We propose to examine the antiviral/antibacterial capacity of N-Halamine textiles, mimicking circumstances under which antimicrobial fabrics must function to reduce infective risks from contamination. Enveloped (VSV) and non- enveloped viruses (EMCV) and antibiotic-resistant bacteria (VRE, MRSA) in blood, body fluids, will be targeted. Quantitative recovery of inocula applied to textiles subjected to different levels of N-Halamine loading will serve to determine survival of organisms. The experiments should establish the potential for incorporating antimicrobial activity into fabrics, and justify longer term evaluation of the approach using a broader range of pathogens, including HIV. This should lead to on-site assessment of protective benefits of N-Halamine clothing. PROPOSED COMMERCIAL APPLICATIONS: If N-Halamine-treated textiles show speed and effectiveness against important types of viral and bacterial pathogens even in blood and other body fluids, and can eventually be shown to decrease occupational exposure of skin and mucous membranes to disease agents, the commercial implications are many. The finding may lead to incorporation of this novel textile chemistry into production of protective clothing and devices for healthcare workers and others (emergency and law enforcement personnel) who may be at risk of occupational exposure to human pathogens.