COLLABORATIVE RESEARCH ON PARASITIC DISEASES IN SUDAN

苏丹寄生虫病合作研究

• 批准号: 3091503
• 负责人: JEFFREY F WILLIAMS
• 金额: $ 28.62万
• 依托单位: BRIGHAM YOUNG UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 1994-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3091503
• 关键词: Africa; parasitic disease chemotherapy; parasitic diseases

The overall project objective is to carry forward a collaborative program of tropical parasitic disease research on several basic problems which underlie the major health priorities of the Republic of Sudan. The solutions we seek should permit inferences to be drawn which are of value to those involved in the characterization, prevention, treatment and control of parasitic diseases elsewhere in the tropics. Four widespread and important human parasitoses will be addressed: malaria, schistosomiasis, onchocerciasis and leishmaniasis. Malaria is by far the most important disease in Sudan; in the absence of chemotherapeutic or vector control interventions the outcome of infection is largely the result of host-immune response - parasite interactions. The nature of these, specifically with regard to T cell responsiveness to defined antigens and the pattern of cell-mediated effector mechanisms in well characterized subsets of endemic area populations form the focus for proposal #1. Contemporary approaches to schistosomiasis in the field depend on widespread use of anthelmintic drugs. The accurate assessment of their impact in terms of pathology and its resolution has only recently become possible using non-invasive ultrasound technology. In proposal #2 we extend our findings on cross-sectional analysis of Symmer;s fibrosis in affected communities to include biochemical and immunological correlates of the onset and disposition of pathologic changes in this most important component of schistosomal disease. The potential impact of ivermectin, a newly developed microfilaricidal agent, on onchocerciasis in Sudan is enormous. However, major questions remain about its pharmacology and mode of action and the role of host-immune responses in its efficacy in vivo and the adverse consequences of treatment. These will be explored in proposal #3 on onchocerciasis. Leishmaniasis, common in rural areas of eastern Sudan, involves immune mechanisms in its pathogenesis which are not well characterized. Longitudinal monitoring of cell-mediated and immunoglobulin types of responses in persons at different disease stages and during and after treatment will be used to establish mechanisms in its pathogenesis which are not well characterized. Longitudinal monitoring of cell-mediated and immunoglobulin types of responses in persons at different disease stages and during and after treatment will be used to establish mechanisms that operate in pathogenesis and after treatment will be used to establish mechanisms that operate in pathogenesis and in the onset of cure and perhaps protection (Project #4. Sustained involvement of Sudanese administrators, professionals, and technicians throughout this program will ensure enhancement of national research capacity for the future, and the research results should contribute to improvements in health care for the affected human populations throughout the country.

该项目的总体目标是推进一个协作方案 热带寄生虫病研究的几个基本问题 这是苏丹共和国的主要卫生优先事项的基础。这个 我们寻求的解决方案应该允许得出有价值的推论 对那些参与表征、预防、治疗和 控制热带其他地区的寄生虫病。四大流传 重要的人类寄生虫病将得到解决：疟疾， 血吸虫病、盘尾丝虫病和利什曼病。疟疾是目前为止 苏丹最重要的疾病；在没有化疗或 媒介控制干预措施感染的后果很大程度上是 宿主-免疫反应-寄生虫相互作用的结果。的性质 这些，特别是关于T细胞的反应性来定义 井下抗原与细胞介导的效应机制模式 疫区人口的特征亚群构成了 提案1.实地防治血吸虫病的当代方法 依赖于驱虫药的广泛使用。准确的评估 它们在病理学上的影响，它的解决只有 最近，使用非侵入性超声技术成为可能。在……里面 提案2我们扩展了我们对以下问题的横断面分析结果 塞默尔；S受影响社区的纤维化包括生化和 病理性疾病发病和处置的免疫学相关性 这一血吸虫病最重要的组成部分的变化。这个 伊维菌素，一种新开发的微丝杀菌剂的潜在影响， 在苏丹，盘尾丝虫病的风险是巨大的。然而，主要问题仍然存在。 关于其药理作用、作用方式及宿主免疫作用 阿司匹林的体内疗效反应及不良后果 治疗。这些问题将在关于盘尾丝虫病的提案3中进行探讨。 利什曼病在苏丹东部农村地区很常见，涉及免疫 其发病机制尚不十分清楚。 细胞介导型和免疫球蛋白类型的纵向监测 不同疾病阶段及病程和病后的反应 治疗将用于建立其发病机制 都不是很好的特征。纵向监测细胞介导的和 不同疾病阶段人群的免疫球蛋白反应类型 在治疗期间和治疗后将被用来建立 在病机运行和治疗后将被用来建立 在发病机制和治愈和发病机制中起作用 也许是保护(项目4.苏丹人的持续参与 整个计划中的管理员、专业人员和技术人员 将确保加强未来的国家研究能力，以及 这项研究结果应该有助于改善 全国受影响的人口。

项目成果

Lack of cross-resistance to 4-aminoquinolines in chloroquine-resistant Plasmodium falciparum in vitro.

体外耐氯喹恶性疟原虫对 4-氨基喹啉缺乏交叉耐药性。

• 发表时间: 1983
• 期刊: The Journal of parasitology
• 作者: Geary,TG;Jensen,JB
• 通讯作者: Jensen,JB

African serum interference in the determination of chloroquine sensitivity in Plasmodium falciparum.

非洲血清干扰恶性疟原虫氯喹敏感性测定。

• DOI: 10.1007/bf00926589
• 发表时间: 1984
• 期刊: Zeitschrift fur Parasitenkunde (Berlin, Germany)
• 作者: Carlin,JM;VandeWaa,JA;Jensen,JB;Akood,MA
• 通讯作者: Akood,MA

Chromosomes of Babesia bovis and Babesia bigemina.

牛巴贝虫和二联巴贝虫的染色体。

• DOI: 10.1016/0166-6851(92)90041-h
• 发表时间: 1992
• 期刊: Molecular and biochemical parasitology
• 影响因子: 1.5
• 作者: Ray,BK;Bailey,CW;Jensen,JB;Carson,CA
• 通讯作者: Carson,CA

Plasma chloroquine measurement in the evaluation of Plasmodium falciparum sensitivity.

血浆氯喹测量评价恶性疟原虫敏感性。

• 发表时间: 1990
• 期刊: The Journal of tropical medicine and hygiene
• 作者: Saeed,BO;Hassabalrasoul,MA;Ibrahim,KE;Abdel-Karim,EI;Salih,SA;Hassan,IM;Khider,S;Bayoumi,RA
• 通讯作者: Bayoumi,RA

AN INVITRO ASSAY SYSTEM FOR THE IDENTIFICATION OF POTENTIAL ANTI-MALARIAL DRUGS

• DOI: 10.2307/3281373
• 发表时间: 1983-01-01
• 期刊: JOURNAL OF PARASITOLOGY
• 影响因子: 1.3
• 作者: GEARY, TG;DIVO, AA;JENSEN, JB
• 通讯作者: JENSEN, JB