MUSCLE ATROPHY AND FOOT DEFORMITY IN DIABETIC ELDERLY

足部问题在老年人中很普遍， 影响流动性。 在糖尿病患者中， 因为人们普遍认为 导致足底溃疡，显著增加风险 下肢截肢手术拟议的研究旨在 检查内在肌萎缩在进展中的假定作用， 足部畸形我们将首先检查对称 远端感觉运动神经病变，足部畸形，以及 在精心选择的受试者组中开发脚趾屈肌扭矩， 糖尿病 然后对足部的MRI进行量化，以评估交叉 重要内在肌的截面积和足底压力 将测量步态。 我们假设感觉和运动 神经病变将广泛平行进行，运动神经病变 与内在肌肉萎缩，足底压力升高， 和抓脚趾。有三个组成部分的意义 of this research研究.首先，它将加强我们对一个 导致老年人失去四肢的重要疾病过程。 其次，它将有助于更好地了解糖尿病 周围神经病变及其后遗症。 第三，最终 从而改善了对有患足风险足部的早期识别 溃疡

Foot problems are widespread in the elderly and have an important influence on mobility. In persons with diabetes, foot deformities are of particular significance because they are widely believed to contribute to plantar ulceration which significantly increases the risk of lower extremity amputation. The proposed research is designed to examine the putative role of intrinsic muscle atrophy in the progression of foot deformity. We will first examine the status of symmetrical distal sensory motor neuropathy, foot deformity, and the ability to develop toe flexor torque in a carefully chosen group of subjects with diabetes. MRI's of the feet will then be quantified to assess cross sectional areas of important intrinsic muscles and plantar pressure during gait will be measured. We hypothesize that sensory and motor neuropathy will proceed broadly in parallel, and that motor neuropathy is associated with intrinsic muscle atrophy, elevated plantar pressure, and clawing of the toes. There are three components to the significance of this research. First, it will enhance our basic understanding of an important disease process that leads to loss of limbs in the elderly. Second, it will contribute to a better understanding of diabetic peripheral neuropathy and its sequelae. Third, it should ultimately lead to an improvement in early recognition of feet that are at risk for ulceration.